Towards 4th generation biomaterials: a covalent hybrid polymer-ormoglass architecture

Nanoscale
N SachotO Castaño

Abstract

Hybrid materials are being extensively investigated with the aim of mimicking the ECM microenvironment to develop effective solutions for bone tissue engineering. However, the common drawbacks of a hybrid material are the lack of interactions between the scaffold's constituents and the masking of its bioactive phase. Conventional hybrids often degrade in a non-homogeneous manner and the biological response is far from optimal. We have developed a novel material with strong interactions between constituents. The bioactive phase is directly exposed on its surface mimicking the structure of the ECM of bone. Here, polylactic acid electrospun fibers have been successfully and reproducibly coated with a bioactive organically modified glass (ormoglass, Si-Ca-P2 system) covalently. In comparison with the pure polymeric mats, the fibers obtained showed improved hydrophilicity and mechanical properties, bioactive ion release, exhibited a nanoroughness and enabled good cell adhesion and spreading after just one day of culture (rMSCs and rEPCs). The fibers were coated with different ormoglass compositions to tailor their surface properties (roughness, stiffness, and morphology) by modifying the experimental parameters. Knowing that cells m...Continue Reading

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Citations

Apr 13, 2018·Regenerative Biomaterials·Ke ZhangXiaoming Li
Nov 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·N SachotE Engel
Oct 31, 2020·Frontiers in Bioengineering and Biotechnology·Ania Naila GuerrieriEnrico Lucarelli

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