Towards a complex system understanding of bipolar disorder: A map based model of a complex winnerless competition

Journal of Theoretical Biology
Fatemeh HadaeghiGreg Murray

Abstract

Bipolar disorder is characterized by repeated erratic episodes of mania and depression, which can be understood as pathological complex system behavior involving cognitive, affective and psychomotor disturbance. In order to illuminate dynamical aspects of the longitudinal course of the illness, we propose here a novel complex model based on the notion of competition between recurrent maps, which mathematically represent the dynamics of activation in excitatory (Glutamatergic) and inhibitory (GABAergic) pathways. We assume that manic and depressive states can be considered stable sub attractors of a dynamical system through which the mood trajectory moves. The model provides a theoretical framework which can account for a number of complex phenomena of bipolar disorder, including intermittent transition between the two poles of the disorder, rapid and ultra-rapid cycling of episodes and manicogenic effects of antidepressants.

References

Jan 1, 1991·Biological cybernetics·G C deGuzman, J A Kelso
Oct 1, 1988·Journal of Clinical Psychopharmacology·N F Damluji, J M Ferguson
Dec 1, 1971·Scientific American·F Attneave
May 3, 2002·Molecular Psychiatry·R S Duman
May 15, 2002·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Nikolai F Rulkov
Oct 4, 2002·Biological Psychiatry·Richard J DavidsonBradley S Peterson
Nov 6, 2003·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Gregory S Berns, Charles B Nemeroff
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·David AngeliEduardo D Sontag
Aug 13, 2004·Journal of Computational Neuroscience·N F RulkovM Bazhenov
Feb 9, 2005·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·G TanakaK Aihara
Mar 15, 2006·Journal of Affective Disorders·Francisco López-MuñozCecilio Alamo
May 3, 2008·PLoS Computational Biology·Mikhail I RabinovichValentin S Afraimovich
Jun 24, 2008·Neuropsychiatric Disease and Treatment·Mani N PavuluriJohn A Sweeney
Dec 19, 2008·Journal of Affective Disorders·Michael BauerPeter C Whybrow
Aug 18, 2010·Bipolar Disorders·Greg Murray, Allison Harvey
Sep 10, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Roy H PerlisGary S Sachs
Sep 30, 2010·PloS One·Mikhail I RabinovichAlexander Bystritsky
Dec 1, 2010·Progress in Biophysics and Molecular Biology·Albert Goldbeter
Feb 16, 2011·Bipolar Disorders·Chi-Hua ChenEd T Bullmore
Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaoqian J ChaiDost Ongür
Jul 1, 2011·Frontiers in Computational Neuroscience·Mikhail I Rabinovich, Pablo Varona
Nov 29, 2011·Physics of Life Reviews·Mikhail I RabinovichPablo Varona
Dec 20, 2011·Trends in Cognitive Sciences·P Read MontaguePeter Dayan
Jan 6, 2012·Trends in Neurosciences·Robert J SchloesserHusseini K Manji
Mar 17, 2012·Bipolar Disorders·Michael A CerulloStephen M Strakowski
Aug 7, 2013·Journal of Neuroscience Methods·M Girardi-SchappoO Kinouchi
Aug 30, 2013·Frontiers in Computational Neuroscience·Fatemeh HadaeghiKeivan Moradi
Sep 7, 2013·Frontiers in Computational Neuroscience·Fatemeh HadaeghiShahriar Gharibzadeh

❮ Previous
Next ❯

Citations

Sep 9, 2016·JMIR Mental Health·Colin DeppWesley Thompson
May 12, 2016·The Australian and New Zealand Journal of Psychiatry·Fatemeh HadaeghiGreg Murray
Feb 3, 2018·Translational Psychiatry·Amy L CochranDaniel B Forger
Jun 17, 2018·Physical Review. E·Carlos Calvo TapiaValeri A Makarov
Nov 11, 2020·ELife·Paolo OssolaCarlo Marchesi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.