Towards a comprehensive endothelial biomarkers profiling and endothelium-guided pharmacotherapy

Pharmacological Reports : PR
Maria WalczakStefan Chlopicki

Abstract

Endothelial dysfunction has prognostic, diagnostic and therapeutic significance in cardiovascular disease, but the endothelial phenotype is still not measured routinely to stratify the cardiovascular risk and tailor therapy. Flow-mediated dilation (FMD), the gold-standard technique for the functional assessment of endothelial function that is increasingly used in clinical settings measures the nitric oxide (NO)-dependent function only. However, the endothelial dysfunction involves a plethora of pathophysiologically important biochemical changes beyond alterations in the NO bioavailability. Still, in many diseases, some plasma protein biomarkers reflecting the pro-thrombotic and the pro-inflammatory endothelial phenotypes have poor selectivity, specificity, and a weak predictive value if they are used alone. Therefore, a multi biomarker strategy seems to be a reasonable and promising alternative. Here, we propose a multi-biomarker strategy to diagnose the endothelial dysfunction and to monitor the efficacy of an endothelium-targeted therapy. This strategy is based on the panel of endothelial biomarkers, reflecting various aspects and mechanisms of dysfunctional endothelium. The potential of an advanced analytical platform like t...Continue Reading

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Citations

Jan 21, 2017·European Journal of Heart Failure·Gilles W De KeulenaerDirk L Brutsaert
Mar 23, 2017·The Journal of Trauma and Acute Care Surgery·Lawrence N DiebelDavid M Liberati
May 29, 2018·European Journal of Clinical Investigation·Angelo ZinelluArduino A Mangoni
Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Feb 23, 2020·Angiology·Ana Rita LeiteAdelino Leite-Moreira
Nov 2, 2018·Journal of Clinical Medicine·Jesus F Bermejo-MartinRaquel Almansa
Aug 20, 2019·Vascular Pharmacology·Anna BarStefan Chlopicki
Jul 3, 2021·International Journal of Molecular Sciences·Marta Martín-FernándezEduardo Tamayo

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