Listeners with normal audiometric thresholds can still have suprathreshold deficits, for example, in the ability to discriminate sounds in complex acoustic scenes. One likely source of these deficits is cochlear neuropathy, a loss of auditory nerve (AN) fibers without hair cell damage, which can occur due to both aging and moderate acoustic overexposure. Since neuropathy can affect up to 50 % of AN fibers, its impact on suprathreshold hearing is likely profound, but progress is hindered by lack of a robust non-invasive test of neuropathy in humans. Reduction of suprathreshold auditory brainstem responses (ABRs) can be used to quantify neuropathy in inbred mice. However, ABR amplitudes are highly variable in humans, and thus more challenging to use. Since noise-induced neuropathy is selective for AN fibers with high thresholds, and because phase locking to temporal envelopes is particularly strong in these fibers, the envelope following response (EFR) might be a more robust measure. We compared EFRs to sinusoidally amplitude-modulated tones and ABRs to tone-pips in mice following a neuropathic noise exposure. EFR amplitude, EFR phase-locking value, and ABR amplitude were all reduced in noise-exposed mice. However, the changes in...Continue Reading
Afferent and efferent innervation of the cat cochlea: quantitative analysis with light and electron microscopy
Characteristics of tone-pip response patterns in relationship to spontaneous rate in cat auditory nerve fibers
Scalp potentials of normal and hearing-impaired subjects in response to sinusoidally amplitude-modulated tones
Morphological differences among radial afferent fibers in the cat cochlea: an electron-microscopic study of serial sections
Ouabain binding kinetics of the rat alpha two and alpha three isoforms of the sodium-potassium adenosine triphosphate
40-Hz steady state response in awake cats after bilateral chronic lesions in auditory cortices or inferior colliculi
Reduced variance in the latency and amplitude of the fifth wave of auditory brain stem response after normalization for head size
Cochlear nerve fiber responses to amplitude-modulated stimuli: variations with spontaneous rate and other response characteristics
Mechanical and "temporal" filtering as codeterminants of the response by cat primary fibers to amplitude-modulated signals
Amplitude modulation following responses in awake and sleeping humans--a comparison for 40 Hz and 80 Hz modulation frequency
Ouabain application to the round window of the gerbil cochlea: a model of auditory neuropathy and apoptosis
Contribution of BK Ca2+-activated K+ channels to auditory neurotransmission in the Guinea pig cochlea
Auditory steady-state responses and word recognition scores in normal-hearing and hearing-impaired adults
Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel
Threshold prediction using the auditory steady-state response and the tone burst auditory brain stem response: a within-subject comparison
Brain-stem auditory evoked responses during microvascular decompression for trigeminal neuralgia: predicting post-operative hearing loss
Abnormal brainstem auditory evoked responses in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): evidence of delayed central conduction time
Auditory evoked responses in the rat: transverse mastoid needle electrodes register before cochlear nucleus and do not reflect later inferior colliculus activity
Detection and differentiation of sensorineural hearing loss in mice using auditory steady-state responses and transient auditory brainstem responses
The clinical value of the multiple-frequency 80-Hz auditory steady-state response in adults with normal hearing and hearing loss
Sox2 up-regulation and glial cell proliferation following degeneration of spiral ganglion neurons in the adult mouse inner ear
Primary neural degeneration in the Guinea pig cochlea after reversible noise-induced threshold shift
Normal hearing is not enough to guarantee robust encoding of suprathreshold features important in everyday communication
Two-channel recording of auditory-evoked potentials to detect age-related deficits in temporal processing
Olivocochlear suppression of outer hair cells in vivo: evidence for combined action of BK and SK2 channels throughout the cochlea
A comparison of spectral magnitude and phase-locking value analyses of the frequency-following response to complex tones
Biological impact of auditory expertise across the life span: musicians as a model of auditory learning
Ouabain-induced cochlear nerve degeneration: synaptic loss and plasticity in a mouse model of auditory neuropathy
Age-related changes in the relationship between auditory brainstem responses and envelope-following responses
Age-Related Changes in Processing Simultaneous Amplitude Modulated Sounds Assessed Using Envelope Following Responses
Evidence that hidden hearing loss underlies amplitude modulation encoding deficits in individuals with and without tinnitus
Tinnitus is associated with reduced sound level tolerance in adolescents with normal audiograms and otoacoustic emissions
Inner Hair Cell Loss Disrupts Hearing and Cochlear Function Leading to Sensory Deprivation and Enhanced Central Auditory Gain
The Influence of Cochlear Mechanical Dysfunction, Temporal Processing Deficits, and Age on the Intelligibility of Audible Speech in Noise for Hearing-Impaired Listeners
Individual Differences in Auditory Brainstem Response Wave Characteristics: Relations to Different Aspects of Peripheral Hearing Loss
Subcortical amplitude modulation encoding deficits suggest evidence of cochlear synaptopathy in normal-hearing 18-19 year olds with higher lifetime noise exposure
Effects of noise exposure on auditory brainstem response and speech-in-noise tasks: a review of the literature
Age-Related Changes in the Auditory Brainstem Response and Suprathreshold Processing of Temporal and Spectral Modulation
Auditory performance in bald eagles and red-tailed hawks: a comparative study of hearing in diurnal raptors
Middle Ear Muscle Reflex and Word Recognition in "Normal-Hearing" Adults: Evidence for Cochlear Synaptopathy?
Bottom-up and top-down neural signatures of disordered multi-talker speech perception in adults with normal hearing.
Brainstem correlates of cochlear nonlinearity measured via the scalp-recorded frequency-following response.
Generalization of the primary tone phase variation method: An exclusive way of isolating the frequency-following response components
Investigating the Effect of Cochlear Synaptopathy on Envelope Following Responses Using a Model of the Auditory Nerve
Photobiomodulation using low-level 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat
Sustained envelope periodicity representations are associated with speech-in-noise performance in difficult listening conditions for younger and older adults
Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors
'Normal' hearing thresholds and fundamental auditory grouping processes predict difficulties with speech-in-noise perception
Cochlear Synaptopathy Changes Sound-Evoked Activity Without Changing Spontaneous Discharge in the Mouse Inferior Colliculus
Acquisition of Subcortical Auditory Potentials With Around-the-Ear cEEGrid Technology in Normal and Hearing Impaired Listeners
Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects.
Hidden Hearing Loss? No Effect of Common Recreational Noise Exposure on Cochlear Nerve Response Amplitude in Humans
Comparison of Silent Gap in Noise Cortical Auditory Evoked Potentials in Matched Tinnitus and No-Tinnitus Control Subjects
Effects of Kainic Acid-Induced Auditory Nerve Damage on Envelope-Following Responses in the Budgerigar (Melopsittacus undulatus).
Enhancing the sensitivity of the envelope-following response for cochlear synaptopathy screening in humans: The role of stimulus envelope
Subcortical neural generators of the envelope-following response in sleeping children: A transfer function analysis.
Correlations between cochlear pathophysiology and behavioral measures of temporal and spatial processing in noise exposed macaques.
Towards Personalized Auditory Models: Predicting Individual Sensorineural Hearing-Loss Profiles From Recorded Human Auditory Physiology.
Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing
Auditory Brainstem Response to Paired Click Stimulation as an Indicator of Peripheral Synaptic Health in Noise-Induced Cochlear Synaptopathy.
Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.
On the use of envelope following responses to estimate peripheral level compression in the auditory system.
Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.