Dec 6, 2006

Towards a muscarinic hypothesis of schizophrenia

Molecular Psychiatry
T J RaedlerBrian Dean

Abstract

Although the neurotransmitter dopamine plays a prominent role in the pathogenesis and treatment of schizophrenia, the dopamine hypothesis of schizophrenia fails to explain all aspects of this disorder. It is increasingly evident that the pathology of schizophrenia also involves other neurotransmitter systems. Data from many streams of research including pre-clinical and clinical pharmacology, treatment studies, post-mortem studies and neuroimaging suggest an important role for the muscarinic cholinergic system in the pathophysiology of schizophrenia. This review will focus on evidence that supports the hypothesis that the muscarinic system is involved in the pathogenesis of schizophrenia and that muscarinic receptors may represent promising novel targets for the treatment of this disorder.

Mentioned in this Paper

Pathogenic Aspects
Pathogenesis
Schizophrenia
Clinical Pharmacology Discipline
Neurotransmitters
Dopamine Measurement
Dopamine
Androgen-Insensitivity Syndrome
Neuroimaging
Physiopathological

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