Towards a Physiological Prandial Insulin Profile: Enhancement of Subcutaneously Injected Prandial Insulin Using Local Warming Devices

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Ahmed H El-Laboudi, Nick Oliver

Abstract

The need to develop an insulin delivery system that can closely mimic physiologically induced changes in prandial insulin release has been a major research target since the discovery of insulin. The challenges facing existing insulin delivery systems, related to relatively slow pharmacokinetics and pharmacodynamics, have been further highlighted by rapid advances in diabetes technology and progress in artificial pancreas research. Despite the growing interest in alternative routes of insulin administration, the subcutaneous route remains-at least for now-the preferred route for insulin administration. In this article, we review efforts aimed at developing subcutaneously injected ultrafast-acting insulin and measures aimed at enhancing insulin absorption, focusing on local warming devices.

References

Aug 30, 1980·British Medical Journal·V A Koivisto
Jul 2, 2003·Diabetes Care·Carol HomkoGuenther Boden
Jun 24, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·S R HellerA Lindholm
Jun 29, 2005·Archives of Internal Medicine·Johannes PlankThomas R Pieber
Jul 22, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·S BottT Heise
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Michael Brownlee, Irl B Hirsch
Aug 2, 2008·Diabetes, Obesity & Metabolism·E MannucciN Marchionni
Jan 29, 2010·Diabetes Technology & Therapeutics·Andrea E ScaramuzzaGian Vincenzo Zuccotti
Feb 11, 2010·Journal of Diabetes Science and Technology·Lutz Heinemann, Yves Jacques
Apr 28, 2012·Journal of Diabetes Science and Technology·Guido FreckmannCornelia Haug
Aug 28, 2012·Journal of Diabetes Science and Technology·Lutz Heinemann, Douglas B Muchmore
Dec 26, 2013·Diabetes Technology & Therapeutics·Eda CengizWilliam V Tamborlane
Mar 13, 2014·Diabetes/metabolism Research and Reviews·Zohar LandauJulio Wainstein
Jul 22, 2014·Clinical Therapeutics·Tricia Santos Cavaiola, Steven Edelman
Jun 4, 2015·Drug Delivery and Translational Research·Christopher James RiniRonald J Pettis

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Citations

Jul 2, 2016·Diabetologia·Hood Thabit, Roman Hovorka
Jul 30, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·L BallyR Hovorka
Dec 21, 2017·International Journal of Pharmaceutics·Lia BallyRoman Hovorka

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