Towards a Physiological Scale of Vocal Fold Agent-Based Models of Surgical Injury and Repair: Sensitivity Analysis, Calibration and Verification

Applied Sciences
Aman GargNicole Y K Li-Jessen

Abstract

Agent based models (ABM) were developed to numerically simulate the biological response to surgical vocal fold injury and repair at the physiological level. This study aimed to improve the representation of existing ABM through a combination of empirical and computational experiments. Empirical data of vocal fold cell populations including neutrophils, macrophages and fibroblasts were obtained using flow cytometry up to four weeks following surgical injury. Random Forests were used as a sensitivity analysis method to identify model parameters that were most influential to ABM outputs. Statistical Parameter Optimization Tool for Python was used to calibrate those parameter values to match the ABM-simulation data with the corresponding empirical data from Day 1 to Day 5 following surgery. Model performance was evaluated by verifying if the empirical data fell within the 95% confidence intervals of ABM outputs of cell quantities at Day 7, Week 2 and Week 4. For Day 7, all empirical data were within the ABM output ranges. The trends of ABM-simulated cell populations were also qualitatively comparable to those of the empirical data beyond Day 7. Exact values, however, fell outside of the 95% statistical confidence intervals. Paramet...Continue Reading

References

Jun 1, 1997·The Surgical Clinics of North America·M B Witte, A Barbul
Jul 14, 2001·Current Problems in Surgery·M C RobsonM G Franz
Mar 29, 2003·Physiological Reviews·Alan R BurnsDavid C Walker
Apr 30, 2003·Nature Immunology·Yuichi WakabayashiRyo Kominami
Nov 25, 2003·The American Journal of Pathology·Jitka Ismail Virag, Charles E Murry
Aug 3, 2004·Nature Reviews. Immunology·Stephen P PerfettoMario Roederer
Aug 24, 2004·Journal of Theoretical Biology·Rukmini KumarCarson C Chow
Oct 16, 2004·Critical Care Medicine·Gilles ClermontCarson Chow
Feb 9, 2005·The Annals of Otology, Rhinology, and Laryngology·Ryan C BranskiPatricia A Hebda
Apr 14, 2005·The Annals of Otology, Rhinology, and Laryngology·Tomoko TateyaDiane M Bless
May 11, 2005·Kidney International·Tsutomu InoueEric G Neilson
May 24, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Shigeru Hirano
Jun 21, 2005·Journal of Voice : Official Journal of the Voice Foundation·Jennifer K Hansen, Susan L Thibeault
Nov 15, 2005·Science·Volker GrimmDonald L DeAngelis
Mar 7, 2006·The Annals of Otology, Rhinology, and Laryngology·Ichiro TateyaDiane M Bless
Apr 1, 2006·The Annals of Otology, Rhinology, and Laryngology·Tomoko TateyaDiane M Bless
May 9, 2006·The Annals of Otology, Rhinology, and Laryngology·Tomoko TateyaDiane M Bless
Jun 21, 2006·Nature Immunology·Leonore A HerzenbergDavid R Parks
Jun 27, 2006·Plastic and Reconstructive Surgery·George BroughtonChristopher E Attinger
Aug 17, 2006·Shock·Yoram VodovotzGilles Clermont
Jan 27, 2007·BMC Bioinformatics·Carolin StroblTorsten Hothorn
Mar 14, 2007·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Enrico LugliAndrea Cossarizza
Sep 29, 2007·Theoretical Biology & Medical Modelling·Virginia A FolcikCharles G Orosz
Mar 1, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Marta Steinbrich-ZöllnerAndreas Grützkau
Mar 25, 2008·The Annals of Otology, Rhinology, and Laryngology·Nathan V WelhamDiane M Bless
May 1, 2008·The Annals of Otology, Rhinology, and Laryngology·Xinhong LimNathan V Welham
May 20, 2008·Journal of Theoretical Biology·S M WiseV Cristini
Jun 24, 2008·Journal of Theoretical Biology·Simeone MarinoDenise E Kirschner
Jul 16, 2008·BMC Bioinformatics·Carolin StroblAchim Zeileis
Dec 18, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sobia IqbalPeter M Tiidus
Apr 8, 2009·Genome Medicine·Charles AuffrayLeroy Hood
May 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Saumyadipta PyneJill P Mesirov
Jul 31, 2009·Journal of Speech, Language, and Hearing Research : JSLHR·Nathan V WelhamDiane M Bless
Dec 17, 2009·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Changying LingNathan V Welham
Dec 22, 2009·The Laryngoscope·Nicole Y K LiYoram Vodovotz
Jan 26, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Patrick AutissierKenneth C Williams
Feb 5, 2010·The Laryngoscope·Summer E HansonSusan L Thibeault
Feb 23, 2010·Immunopharmacology and Immunotoxicology·Yoram VodovotzGary An
Jun 29, 2010·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Enrico LugliAndrea Cossarizza

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Citations

Jul 16, 2020·Bioscience Reports·Haizhou WangWen Xu
Jul 18, 2020·Tissue Engineering and Regenerative Medicine·Jeong-Seok ChoiJae-Yol Lim

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