Towards a practical management of fatigue in systemic lupus erythematosus.

Lupus Science & Medicine
Philippe MertzLaurent Arnaud

Abstract

Significant fatigue is reported by two-thirds of patients with SLE and severe fatigue by one-third. The assessment and treatment of fatigue remains a major challenge in SLE, especially in patients with no disease activity. Here, we suggest a practical algorithm for the management of fatigue in SLE. First, common but non-SLE-related causes of fatigue should be ruled out based on medical history, clinical and laboratory examinations. Then, presence of SLE-related disease activity or organ damage should be assessed. In patients with active disease, remission is the most appropriate therapeutic target while symptomatic support is needed in case of damage. Both anxiety and depression are major independent predictors of fatigue in SLE and require dedicated assessment and care with psychological counselling and pharmacological intervention if needed. This practical algorithm will help in improving the management of one the most common and complex patient complaints in SLE.

References

Feb 13, 2003·Arthritis and Rheumatism·Randall E KeyserBarry S Handwerger
May 30, 2003·Digestive Diseases and Sciences·Yoshiko KadokawaShigeru Kohno
Apr 9, 2005·Arthritis and Rheumatism·Deborah Da CostaChristian Pineau
Feb 28, 2007·Annals of the Rheumatic Diseases·Nathalie Costedoat-ChalumeauJean-Charles Piette
Sep 18, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·E HarboeR Omdal
Nov 13, 2008·The Journal of Rheumatology·Frederick WolfeElizabeth W Karlson
Apr 19, 2011·Autoimmunity Reviews·Sandor Balsamo, Leopoldo Dos Santos-Neto
Nov 15, 2011·Musculoskeletal Care·Stephanie NikolausMart Afj van de Laar
Mar 5, 2014·Autoimmune Diseases·R FonsecaM Figueiredo-Braga
Apr 4, 2014·Kidney International·Micol ArtomJoseph Chilcot
Oct 21, 2014·Therapeutics and Clinical Risk Management·Hon K Yuen, Melissa A Cunningham
Mar 18, 2015·Arthritis & Rheumatology·John G HanlyVernon Farewell
Jul 6, 2016·Annals of the Rheumatic Diseases·G J MacfarlaneG T Jones
Oct 25, 2016·Autoimmunity Reviews·M Schneider
Mar 21, 2017·The American Journal of the Medical Sciences·Avinash Adiga, Kenneth Nugent
Mar 6, 2018·PloS One·Domenico Paolo Emanuele MargiottaAntonella Afeltra
Feb 8, 2019·Lupus Science & Medicine·Renaud FeltenLaurent Arnaud
Jun 6, 2019·American Journal of Nephrology·L Parker GreggS Susan Hedayati

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Citations

Jan 15, 2021·Journal of Clinical Medicine·Matteo Piga, Laurent Arnaud
Feb 17, 2021·Lupus·Peter Korsten, Silvia Piantoni

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