Towards a quantitative model to predict the toxicity/pathogenicity potential of mineral fibers

Toxicology and Applied Pharmacology
Alessandro F Gualtieri

Abstract

Some mineral fibers represent a health hazard because they are classified as cancer-causing chemical/physical toxicants upon (chronic) dust inhalation. Although in the last decades they have been the subject of intensive multidisciplinary investigations, the mechanisms by which mineral fibers induce toxic and pathogenic adverse effects on human health and environment are not yet fully understood. The major intricacy of the biological approach that prevents the design of a conclusive shared model of behavior of mineral fibers in a biological system stems from their very nature with intrinsic variability in chemical, molecular, structural and morphometric parameters, biodurability and surface reactivity. This paper presents the first attempt to devise a quantitative predictive model of toxicity/pathogenicity of minerals fibers based on their physical/chemical and morphological parameters. Although the author is aware that all parameters should be measured in comparable in vivo systems that accurately simulate the lung and or pleural environment, this preliminary model was conceived to deliver a fiber potential toxicity/pathogenicity index (FPTI) to be integrated with the biological approach so to create a quantitative predictive ...Continue Reading

Citations

Dec 5, 2019·Journal of Applied Crystallography·Carlotta GiacobbeAlessandro F Gualtieri
Jan 22, 2021·Environmental Geochemistry and Health·Andrea BloiseDolores Pereira
Mar 7, 2021·Toxicology·Alessandro F GualtieriDario Di Giuseppe
Aug 5, 2021·Current Research in Toxicology·Ann G Wylie, Andrey A Korchevskiy

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