Towards adaptive IMRT sequencing for the MR-linac

Physics in Medicine and Biology
Charis KontaxisB W Raaymakers

Abstract

The MRI linear accelerator (MR-linac) that is currently being installed in the University Medical Center Utrecht (Utrecht, The Netherlands), will be able to track the patient's target(s) and Organ(s) At Risk during radiation delivery. In this paper, we present a treatment planning system for intensity-modulated radiotherapy (IMRT). It is capable of Adaptive Radiotherapy and consists of a GPU Monte Carlo dose engine, an inverse dose optimization algorithm and a novel adaptive sequencing algorithm. The system is able to compensate for patient anatomy changes and enables radiation delivery immediately from the first calculated segment. IMRT plans meeting all clinical constraints were generated for two breast cases, one spinal bone metastasis case, two prostate cases with integrated boost regions and one head and neck case. These plans were generated by the segment weighted version of our algorithm, in a 0 T environment in order to test the feasibility of the new sequencing strategy in current clinical conditions, yielding very small differences between the fluence and sequenced distributions. All plans went through stringent experimental quality assurance on Delta4 and passed all clinical tests currently performed in our institute...Continue Reading

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Citations

Jul 23, 2015·Acta Oncologica·Jean-Philippe Pignol, Cecile Janus
Sep 4, 2015·Medical Physics·Ashley E RubinsteinLaurence E Court
Sep 8, 2016·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P Maingon
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Nov 30, 2018·Medical Physics·Johannes GreberKlaus Bratengeier
Jan 23, 2019·Physics in Medicine and Biology·Filipa GuerreiroBas W Raaymakers
Dec 7, 2019·Journal of Applied Clinical Medical Physics·Richard Y WuSteven J Frank
May 30, 2020·Physics in Medicine and Biology·Bastiaan Wilhelmus Klaas SchipaanboordSebastiaan Breedveld
Feb 14, 2020·Physics in Medicine and Biology·C KontaxisB W Raaymakers
Sep 16, 2015·Physics in Medicine and Biology·Charis KontaxisB W Raaymakers
Nov 5, 2015·Physics in Medicine and Biology·M GlitznerB W Raaymakers
Feb 9, 2020·Radiation Oncology·Rasmus Lübeck ChristiansenUffe Bernchou
Dec 6, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nikolai J Mickevicius, Eric S Paulson
Jul 14, 2017·Medical Physics·Charis KontaxisBas W Raaymakers
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Aug 1, 2019·Biomedical Physics & Engineering Express·Rodney D Wiersma, Xinmin Liu
Feb 20, 2021·Physics in Medicine and Biology·Lars MejnertsenPaul Keall
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Aug 19, 2021·Physics in Medicine and Biology·Maryam MoteabbedThomas R Bortfeld

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