Towards an integrated venomics approach for accelerated conopeptide discovery

Toxicon : Official Journal of the International Society on Toxinology
Jutty Rajan PrashanthSébastien Dutertre

Abstract

Conopeptides and conotoxins are small peptides produced by cone snails as a part of their predatory/defense strategies that target key ion channels and receptors in the nervous system. Some of these peptides also potently target mammalian ion channels involved in pain pathways. As a result, these venoms are a source of valuable pharmacological and therapeutic agents. The traditional approach towards conopeptide discovery relied on activity-guided fractionation, which is time consuming and resource-intensive. In this review, we discuss the advances in the fields of transcriptomics, proteomics and bioinformatics that now allow researchers to integrate these three platforms towards a more efficient discovery strategy. In this review, we also highlight the challenges associated with the wealth of data generated with this integrated approach and briefly discuss the impact these methods could have on the field of toxinology.

References

Apr 29, 2003·Briefings in Bioinformatics·Paul T J TanVladimir Brusic
Oct 4, 2003·Nature Reviews. Drug Discovery·Richard J Lewis, Maria L Garcia
Jan 13, 2004·Physiological Reviews·Heinrich Terlau, Baldomero M Olivera
Apr 15, 2004·Biochemical and Biophysical Research Communications·Sadasivannair SudarslalPadmanabhan Balaram
Nov 25, 2004·The Journal of Biological Chemistry·Olga BuczekBaldomero M Olivera
Jul 27, 2005·The Journal of Experimental Biology·Jennifer A JakubowskiJoseph R Schulz
Nov 30, 2005·Cellular and Molecular Life Sciences : CMLS·O BuczekB M Olivera
Feb 8, 2006·Toxicon : Official Journal of the International Society on Toxinology·André MénezDietrich Mebs
Apr 1, 2006·Toxicon : Official Journal of the International Society on Toxinology·Loïc QuintonJulia Chamot-Rooke
Apr 22, 2006·Toxicon : Official Journal of the International Society on Toxinology·Philippe FavreauReto Stöcklin
Aug 15, 2006·The Journal of Biological Chemistry·Baldomero M Olivera
Jun 5, 2007·Journal of the American Society for Mass Spectrometry·Amit Kumar MandalPadmanabhan Balaram
Dec 11, 2007·Bioinformatics·Quentin KaasDavid J Craik
Feb 13, 2008·Journal of Separation Science·Cristina RomeoMaria Eugenia Schininà
Feb 28, 2008·Journal of Mass Spectrometry : JMS·P EscoubasG M Nicholson
Jul 16, 2008·Toxicon : Official Journal of the International Society on Toxinology·Jason S BiggsYuri I Kantor
Aug 6, 2008·Current Opinion in Chemical Biology·Grzegorz Bulaj
Oct 11, 2008·Nature Biotechnology·Jay Shendure, Hanlee Ji
Apr 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Beatrix M UeberheideBrian T Chait
May 12, 2009·Nucleic Acids Research·Guy NaamatiMichal Linial
May 22, 2009·Journal of Proteomics·Daniel BiassReto Stöcklin
Jun 23, 2009·Peptides·Jasmine DavisRichard J Lewis
Jun 23, 2009·Current Opinion in Pharmacology·Philippe Favreau, Reto Stöcklin
Nov 4, 2009·Biochemical Pharmacology·Irina Vetter, Richard J Lewis
Feb 24, 2010·Amino Acids·Irina VetterGlenn F King
Mar 9, 2010·Toxicon : Official Journal of the International Society on Toxinology·Sébastien DutertrePhilippe Favreau
Sep 8, 2010·Journal of Proteome Research·Helena Safavi-HemamiAnthony W Purcell
Jul 21, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Mohamed A Abdel-RahmanPeter N Strong
Nov 15, 2011·Toxicon : Official Journal of the International Society on Toxinology·Yves TerratFrédéric Ducancel
Mar 13, 2012·Pharmacological Reviews·Richard J LewisMacDonald J Christie

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Citations

Jun 21, 2014·Chemical Communications : Chem Comm·Grégory UpertNicolas Gilles
Nov 19, 2014·Future Medicinal Chemistry·Jutty Rajan PrashanthRichard J Lewis
Nov 19, 2014·Future Medicinal Chemistry·Brad R GreenRaymond S Norton
Nov 19, 2014·Future Medicinal Chemistry·Frédéric DucancelMarion Verdenaud
Mar 5, 2013·Marine Drugs·Gerrit J GerwigRolf Boelens
Jun 26, 2015·Toxins·Quentin Kaas, David J Craik
Sep 17, 2015·Toxicon : Official Journal of the International Society on Toxinology·Jutty Rajan Prashanth, Richard J Lewis
Sep 1, 2015·Journal of Proteome Research·S W A HimayaRichard J Lewis
Jun 26, 2012·Toxicon : Official Journal of the International Society on Toxinology·Juan J Calvete
Jun 7, 2015·Analytical and Bioanalytical Chemistry·Alena M RodriguezFrank Marí
May 15, 2013·Toxicon : Official Journal of the International Society on Toxinology·Clifford A KaponoJon-Paul Bingham
Apr 19, 2016·International Journal of Molecular Sciences·Bing XieQiong Shi
Oct 28, 2016·Molecular BioSystems·Vera OldratiReto Stöcklin
Dec 26, 2016·Biochimica Et Biophysica Acta. General Subjects·Johara Boldrini-FrançaEliane Candiani Arantes
Nov 16, 2012·Molecular & Cellular Proteomics : MCP·Sébastien DutertreRichard J Lewis
Nov 2, 2017·Molecular BioSystems·Jutty Rajan PrashanthRichard James Lewis
Jun 15, 2018·Marine Drugs·Nikita Abraham, Richard J Lewis
Jul 12, 2018·Journal of Cellular and Molecular Medicine·Bin LiHang Fai Kwok
Oct 17, 2018·Scientific Reports·Anders ErikssonAdam Claridge-Chang
Mar 6, 2019·Marine Drugs·Rachael A MansbachS Gnanakaran
Jul 26, 2018·High-throughput·David Wilson, Norelle L Daly
Jun 8, 2021·RSC Medicinal Chemistry·Ashlin TurnerDavid J Craik

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