Towards an understanding of organic anion transporters: structure-function relationships

Medicinal Research Reviews
Guofeng You

Abstract

Organic anion transporters (OAT) play essential roles in the body disposition of clinically important anionic drugs, including anti-viral drugs, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories. The activities of OATs are directly linked to drug toxicity and drug-drug interactions. So far, four members of the OAT family have been identified: OAT1, OAT2, OAT3, and OAT4. These transporters share several common structural features including 12 transmembrane domains, multiple glycosylation sites localized in the first extracellular loop between transmembrane domains 1 and 2, and multiple phosphorylation sites present in the intracellular loop between transmembrane domains 6 and 7, and in the carboxyl terminus. The impact of these structural features on the function of these transporters has just begun to be explored. In the present review, the author will summarize recent progress made from her laboratory as well as from others, on the molecular characterization of the structure-function relationships of OATs, including particular amino acid residues/regions of the transporter protein ("molecular domains") that potentially determine transport characteristics.

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Citations

Nov 15, 2006·Pharmaceutical Research·Fanfan Zhou, Guofeng You
Mar 14, 2009·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Peng Duan, Guofeng You
Mar 20, 2010·The Journal of Pharmacology and Experimental Therapeutics·Shanshan LiGuofeng You
Dec 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·Shanshan LiGuofeng You
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Nov 1, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fanfan ZhouGuofeng You
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Apr 18, 2008·European Journal of Pharmacology·Azza A K El-SheikhFrans G M Russel
Jul 28, 2005·The Journal of Biological Chemistry·Mei HongGuofeng You
Aug 22, 2006·The Journal of Biological Chemistry·Wen XuGuofeng You
Aug 1, 2008·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C SrimaroengJ B Pritchard
Aug 8, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wei WuSanjay K Nigam
Jul 8, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Caroline Prouillac, Sylvaine Lecoeur
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Nov 18, 2005·American Journal of Physiology. Renal Physiology·Andrew R ErdmanKathleen M Giacomini
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