Towards breast tomography with synchrotron radiation at Elettra: first images

Physics in Medicine and Biology
R LongoF Zanconati

Abstract

The aim of the SYRMA-CT collaboration is to set-up the first clinical trial of phase-contrast breast CT with synchrotron radiation (SR). In order to combine high image quality and low delivered dose a number of innovative elements are merged: a CdTe single photon counting detector, state-of-the-art CT reconstruction and phase retrieval algorithms. To facilitate an accurate exam optimization, a Monte Carlo model was developed for dose calculation using GEANT4. In this study, high isotropic spatial resolution (120 μm)(3) CT scans of objects with dimensions and attenuation similar to a human breast were acquired, delivering mean glandular doses in the range of those delivered in clinical breast CT (5-25 mGy). Due to the spatial coherence of the SR beam and the long distance between sample and detector, the images contain, not only absorption, but also phase information from the samples. The application of a phase-retrieval procedure increases the contrast-to-noise ratio of the tomographic images, while the contrast remains almost constant. After applying the simultaneous algebraic reconstruction technique to low-dose phase-retrieved data sets (about 5 mGy) with a reduced number of projections, the spatial resolution was found to b...Continue Reading

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Citations

May 11, 2016·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·A SarnoP Russo
Oct 12, 2016·Medical Engineering & Physics·Antonio SarnoPaolo Russo
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Nov 13, 2018·Physics in Medicine and Biology·Marco CaballoIoannis Sechopoulos
Jun 25, 2019·Physics in Medicine and Biology·Anna PiaiRenata Longo
Jul 6, 2019·Journal of Synchrotron Radiation·Renata LongoGiuliana Tromba
Aug 5, 2017·Physics in Medicine and Biology·N MartiniG Nikiforidis
Sep 13, 2019·Scientific Reports·Pasquale DeloguPiernicola Oliva
Mar 11, 2020·Journal of Synchrotron Radiation·Sandro DonatoDiego Dreossi
Apr 12, 2017·Physics in Medicine and Biology·G MettivierP Russo
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Aug 8, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Stoyko MarinovKristina Bliznakova
Mar 10, 2018··Deborah BonazzaAngelo Taibi

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