Towards Clinical Implementation of Adeno-Associated Virus (AAV) Vectors for Cancer Gene Therapy: Current Status and Future Perspectives

Cancers
Ulrich T HackerHildegard Büning

Abstract

Adeno-associated virus (AAV) vectors have gained tremendous attention as in vivo delivery systems in gene therapy for inherited monogenetic diseases. First market approvals, excellent safety data, availability of large-scale production protocols, and the possibility to tailor the vector towards optimized and cell-type specific gene transfer offers to move from (ultra) rare to common diseases. Cancer, a major health burden for which novel therapeutic options are urgently needed, represents such a target. We here provide an up-to-date overview of the strategies which are currently developed for the use of AAV vectors in cancer gene therapy and discuss the perspectives for the future translation of these pre-clinical approaches into the clinic.

References

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Citations

Jan 28, 2021·Cancer Cell International·Xin XuXiaochun Zhang
Aug 17, 2021·Frontiers in Immunology·Marion ArnaudAlexandre Harari
Oct 30, 2021·Macromolecular Rapid Communications·Teoman Benli-HoppeMina Yazdi

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Methods Mentioned

BETA
SMA
genetic modification
xenograft
phage display
peptide display
xenografts
transfection

Clinical Trials Mentioned

NCT00979238

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