Towards control of cellulose biosynthesis by Komagataeibacter using systems-level and strain engineering strategies: current progress and perspectives.

Applied Microbiology and Biotechnology
Małgorzata RyngajłłoStanisław Bielecki

Abstract

The strains of the Komagataeibacter genus have been shown to be the most efficient bacterial nanocellulose producers. Although exploited for many decades, the studies of these species focused mainly on the optimisation of cellulose synthesis process through modification of culturing conditions in the industrially relevant settings. Molecular physiology of Komagataeibacter was poorly understood and only a few studies explored genetic engineering as a strategy for strain improvement. Only since recently the systemic information of the Komagataeibacter species has been accumulating in the form of omics datasets representing sequenced genomes, transcriptomes, proteomes and metabolomes. Genetic analyses of the mutants generated in the untargeted strain modification studies have drawn attention to other important proteins, beyond those of the core catalytic machinery of the cellulose synthase complex. Recently, modern molecular and synthetic biology tools have been developed which showed the potential for improving targeted strain engineering. Taking the advantage of the gathered knowledge should allow for better understanding of the genotype-phenotype relationship which is necessary for robust modelling of metabolism as well as sele...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Tânia AlmeidaCarmen S R Freire
Jul 2, 2021·Materials Today. Bio·O Burgos-MoralesW Weber
Sep 15, 2021·Bioengineered·Reeta Rani SinghaniaCheng Di Dong
Nov 25, 2021·Microbial Biotechnology·Ana M Hernández-ArriagaM Auxiliadora Prieto

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Datasets Mentioned

BETA
ATCC
23769

Methods Mentioned

BETA
Immunoprecipitation
RNA-seq
electrophoresis
environmental stress
genetic modifications
biosensors
genetic modification

Software Mentioned

BLAST +
PYANI

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