Towards definitive management of allergic rhinitis: best use of new and established therapies

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Lubnaa HossenbaccusAnne K Ellis

Abstract

Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa impacting up to 25% of Canadians. The standard of care for AR includes a treatment plan that takes into account patient preferences, the severity of the disease, and most essentially involves a shared decision-making process between patient and provider. Since their introduction in the 1940s, antihistamines (AHs) have been the most utilized class of medications for the treatment of AR. First-generation AHs are associated with adverse central nervous system (CNS) and anticholinergic side effects. On the market in the 1980s, newer generation AHs have improved safety and efficacy. Compared to antihistamines, intranasal corticosteroids (INCS) have significantly greater efficacy but longer onset of action. Intranasal AH and INCS combinations offer a single medication option that offers broader disease coverage and faster symptom control. However, cost and twice-per-day dosing remain a major limitation. Allergen immunotherapy (AIT) is the only disease-modifying option and can be provided through subcutaneous (SCIT) or sublingual (SLIT) routes. While SCIT has been the definitive management option for many years, SLIT tablets (SLIT-T) have also been proven to be safe...Continue Reading

References

Nov 1, 1996·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A J WeidoT C Sim
Aug 1, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J H DayP Gervais
Jan 20, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J H DayJ Mason
Aug 12, 1999·The New England Journal of Medicine·S R DurhamK T Nouri-Aria
Aug 19, 1999·The Journal of Allergy and Clinical Immunology·E F JuniperJ N Roberts
Nov 15, 2001·The Journal of Allergy and Clinical Immunology·J BousquetUNKNOWN World Health Organization
Apr 26, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R LeursM Taglialatela
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C MöllerH Hildebrand
Feb 3, 1951·Journal of the American Medical Association·J B WYNGAARDEN, M H SEEVERS
Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Elizabeth F JuniperPeter H Howarth
Mar 8, 2005·International Journal of Cardiology·John W Sype, Ijaz A Khan
Jun 6, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Elizabeth J ScharmanWilliam G Troutman
Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Peters-GoldenA Togias
Sep 15, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Deborah LaytonSaad A W Shakir
Dec 18, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G K ScaddingUNKNOWN British Society for Allergy and Clinical Immunology
Feb 8, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Paul H RatnerHarry Sacks
Mar 25, 2008·Therapeutics and Clinical Risk Management·De-Yun Wang
Jul 31, 2008·The Journal of Allergy and Clinical Immunology·Dana V WallaceUNKNOWN Joint Council of Allergy, Asthma and Immunology
Feb 27, 2009·Ophthalmology·Jie Jin WangPaul Mitchell
Nov 28, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Friedrich HorakPatrick Lemell
Feb 11, 2010·The Journal of Allergy and Clinical Immunology·Linda CoxGiovanni Passalacqua
Feb 12, 2010·Allergy·M K ChurchUNKNOWN Global Allergy and Asthma European Network
Mar 5, 2010·The Journal of Allergy and Clinical Immunology·Mark S Dykewicz, Daniel L Hamilos
Apr 27, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Cemal Cingi, Samet Ozlugedik
May 19, 2010·Expert Review of Clinical Immunology·Friedrich Horak, Ursula Petra Zieglmayer
Jun 15, 2005·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Celine Bergeron, Qutayba Hamid
Aug 19, 2010·The Laryngoscope·Cemal CingiHalis Unlu
Aug 13, 2011·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Demin HanUNKNOWN Chinese Allergic Rhinitis Collaborative Research Group (C2AR2G)
Nov 1, 2011·The Journal of Allergy and Clinical Immunology·F Estelle R Simons, Keith J Simons
Mar 16, 2012·The Journal of Allergy and Clinical Immunology·Warner CarrJean Bousquet
Jun 5, 2012·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Paul K KeithSusan Waserman
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Cheryl S HankinZhaohui Wang
May 9, 2013·International Archives of Allergy and Immunology·Eli MeltzerJean Bousquet
Jun 1, 2013·Indian Journal of Dermatology·Martin K Church, Diana S Church
Jul 25, 2013·Current Allergy and Asthma Reports·Michael R NelsonCecilia P Mikita
Nov 26, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michail AlevizosTheoharis C Theoharides

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Citations

Apr 27, 2021·Clinical and Translational Allergy·Anne M SalapatekAndreas Bilstein
May 18, 2021·Frontiers in Pharmacology·Salinee JantrapiromNutthiya Hanprasertpong
May 25, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Susan WasermanErnie Avilla
Jul 1, 2021·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Yan FengLei Cheng
Jun 22, 2021·The Journal of Allergy and Clinical Immunology·Cristina Benito-VillalvillaOscar Palomares
Sep 22, 2021·American Journal of Rhinology & Allergy·Kathy ZhangRodney J Schlosser

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Methods Mentioned

BETA
pharmacotherapy
sedation

Software Mentioned

SLIT

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