Towards designer microparticles: simultaneous control of anisotropy, shape, and size

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Srijanani BhaskarJoerg Lahann

Abstract

Biodegradable, compositionally anisotropic microparticles with two distinct compartments that exhibit controlled shapes and sizes are fabricated. These multifunctional particles are prepared by electrohydrodynamic co-jetting of poly(lactide-co-glycolide) polymer solutions. By varying different solution and process parameters, namely, concentration and flow rate, a variety of non-equilibrium bicompartmental shapes, such as discoid and rod-shaped microparticles are produced in high yields. Optimization of jetting parameters, combined with filtration, results in near-perfect, bicompartmental spherical particles in the size range of 3-5 microm. Simultaneous control over anisotropy, size, shape, and surface structure provides an opportunity to create truly multifunctional microparticles for a variety of biological applications, such as drug delivery, diagnostic assays, and theranostics.

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Citations

May 18, 2012·ACS Applied Materials & Interfaces·Robertus Wahyu N NugrohoAnn-Christine Albertsson
Oct 12, 2013·ACS Applied Materials & Interfaces·Jaewon YoonJoerg Lahann
Apr 6, 2013·Chemical Reviews·Andreas Walther, Axel H E Müller
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May 19, 2012·Macromolecular Rapid Communications·Sangyeul Hwang, Joerg Lahann
Dec 14, 2011·Angewandte Chemie·Sampa SahaJoerg Lahann
Mar 25, 2011·Macromolecular Rapid Communications·Kyung Jin LeeJoerg Lahann
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Jul 6, 2016·Pharmaceutical Research·Sharan Bobbala, Sarah Hook
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Feb 7, 2018·Advanced Healthcare Materials·Asish C Misra, Joerg Lahann
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Jul 2, 2020·Macromolecular Rapid Communications·Fabian BeckerJoerg Lahann
Jan 4, 2017·Macromolecular Rapid Communications·Jacob H JordahlJoerg Lahann
Jun 20, 2016·Bioengineering & Translational Medicine·Sahar RahmaniJoerg Lahann

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