Towards Functional Droplet Architectures: a Belousov-Zhabotinsky Medium for Networks

Scientific Reports
Kai Ming ChangKlaus-Peter Zauner

Abstract

The confluence of droplet-compartmentalised chemical systems and architectures composed of interacting droplets points towards a novel technology mimicking core features of the cellular architecture that dominates biology. A key challenge to achieve such a droplet technology is long-term stability in conjunction with interdroplet communication. Here, we probed the parameter space of the Belousov-Zhabotinsky (BZ) medium, an extensively studied model for non-equilibrium chemical reactions, pipetted as 2.5 mm droplets in hexadecane oil. The presence of asolectin lipids enabled the formation of arrays of contacted BZ droplets, of which the wave patterns were characterised over time. We utilised laser-cut acrylic templates with over 40 linear oil-filled slots in which arrays are formed by pipetting droplets of the desired BZ composition, enabling parallel experiments and automated image analysis. Using variations of conventional malonic acid BZ medium, wave propagation over droplet-droplet interfaces was not observed. However, a BZ medium containing both malonic acid and 1,4-cyclohexanedione was found to enable inter-droplet wave propagation. We anticipate that the chemical excitation properties of this mixed-substrate BZ medium, in...Continue Reading

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Citations

Feb 6, 2020·Angewandte Chemie·Alejandro Méndez-ArdoyJavier Montenegro
Jun 25, 2020·Angewandte Chemie·Qing ShaoYongfeng Zhou
Jul 8, 2020·Materials·Alina OsypovaGuido Panzarasa
Nov 11, 2019·Emerging Topics in Life Sciences·Hagan BayleyCharlotte E G Hoskin
Sep 3, 2021·The Journal of Physical Chemistry. B·Boris KichatovAlexey Kiverin

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Software Mentioned

VIMBA
Origin Peak Analyser
CorelDRAW Graphics Suite
ImageJ
Origin

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