Towards Human Oxygen Images with Electron Paramagnetic Resonance Imaging

Advances in Experimental Medicine and Biology
Boris EpelHoward J Halpern

Abstract

Electron paramagnetic resonance imaging (EPRI) has been used to noninvasively provide 3D images of absolute oxygen concentration (pO2) in small animals. These oxygen images are well resolved both spatially (~1 mm) and in pO2 (1-3 mmHg). EPRI preclinical images of pO2 have demonstrated extremely promising results for various applications investigating oxygen related physiologic and biologic processes as well as the dependence of various disease states on pO2, such as the role of hypoxia in cancer. Recent developments have been made that help to progress EPRI towards the eventual goal of human application. For example, a bimodal crossed-wire surface coil has been developed. Very preliminary tests demonstrated a 20 dB isolation between transmit and receive for this coil, with an anticipated additional 20 dB achievable. This could potentially be used to image local pO2 in human subjects with superficial tumors with EPRI. Local excitation and detection will reduce the specific absorption rate limitations on images and eliminate any possible power deposition concerns. Additionally, a large 9 mT EPRI magnet has been constructed which can fit and provide static main and gradient fields for imaging local anatomy in an entire human. One ...Continue Reading

Citations

Jul 2, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Valérie MarchandBernard Gallez
Nov 9, 2017·Contrast Media & Molecular Imaging·Gigin LinJae Mo Park
Dec 30, 2020·International Journal of Radiation Oncology, Biology, Physics·Gage RedlerRodney D Wiersma
Jun 3, 2021·International Journal of Molecular Sciences·Thomas PrudhommeJulien Branchereau
May 26, 2017·Zeitschrift für physikalische Chemie·Andrey A KuzhelevElena G Bagryanskaya
Jul 3, 2021·Journal of Personalized Medicine·Paolo CastorinaGianluca Ferini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.