Towards measles elimination in Italy: Virological surveillance and genotypes trend (2013-2015)

Virus Research
F MaguranoMeasles Surveillance Group

Abstract

In accordance with the goal of the World Health Organization Regional Office for Europe, the Italian National Measles and Rubella Elimination Plan aimed to interrupt indigenous measles transmission in Italy by the end of 2015. However, from 2013 to 2015, Italy experienced high measles burden with 4902 measles cases (49.3% laboratory-confirmed) reported to the enhanced measles surveillance system (cumulative incidence in the triennium reference period: 2.4/100,000 population). The measles elimination goal was not reached. Laboratory surveillance of measles circulating genotypes is performed by the Measles and Rubella National Reference Laboratory (NRL) at the Italian National Institute of Health (Istituto Superiore di Sanità - ISS), in Rome. Samples received from 1 January 2013-31 December 2015 were analysed. Those positive for measles genome by molecular tests were sequenced and phylogenetically analysed. Phylogenetic analysis performed by NRL identified that genotypes D4 and D8 were endemic and co-circulated in 2011-2013: study results show that genotype D4 disappeared during 2013. Sporadic cases were associated to genotype B3 during 2011-2013, which became endemic in Italy during 2014 and co-circulated with D8 until 2015. Spo...Continue Reading

Citations

Oct 19, 2017·Expert Review of Vaccines·James L GoodsonWalter A Orenstein
Jul 25, 2019·Frontiers in Microbiology·Fumio SekiUNKNOWN Technical Support Team for Measles Control in Japan
Mar 18, 2020·Infectious Diseases·Luca CoppetaAntonio Pietroiusti
Sep 12, 2020·Journal of Public Health·Serena MarchiClaudia Maria Trombetta
Aug 26, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Antonella AmendolaElisabetta Tanzi
Feb 17, 2019·BMC Public Health·Oyunchimeg OrsooNobuyuki Hamajima
Mar 22, 2019·Annals of Global Health·Fabiana FiascaAntonella Mattei
Mar 27, 2020·Human Vaccines & Immunotherapeutics·Valentina BaccoliniCorrado De Vito
Jun 26, 2020·International Journal of Molecular Sciences·Silvia BianchiAntonella Amendola

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