Towards metal-mediated g-quartet analogues: 1,2,4-triazole nucleotides

Nucleosides, Nucleotides & Nucleic Acids
Jamie M WithersVyacheslav V Filichev

Abstract

We proposed that metal-coordinating nucleotides could be used to control the assembly of G-quadruplexes through the formation of an artificial metal-centered quartet. Several guanine-rich DNA sequences containing 1,2,4-triazole-functionalized nucleotides were investigated. These oligonucleotides were designed to form quartets mediated by metal-triazole bonding both on the surface of and within the G-quadruplex core. In contrast to duplex studies in which 1,2,4-triazole nucleosides serve as a mimic of Watson-Crick base-pairs, our results show that these nucleosides are not suitable components of an artificial metal-centered quartet.

References

Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R JinK J Breslauer
Jun 18, 1996·Biochemistry·J R WyattS M Freier
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·C SchaffitzelA Plückthun
Jan 12, 2005·Nucleic Acids Research·Jean-Louis MergnyLaurent Lacroix
Aug 3, 2005·Chemistry : a European Journal·Jens MüllerMichael Roitzsch
Oct 3, 2006·Nucleic Acids Research·Sarah BurgeStephen Neidle
Dec 8, 2006·Nucleic Acids Symposium Series·Daisuke MiyoshiNaoki Sugimoto
Jan 9, 2007·Journal of Inorganic Biochemistry·Jens MüllerFabian-Alexander Polonius
Apr 19, 2007·Journal of the American Chemical Society·Daisuke MiyoshiNaoki Sugimoto
Jul 21, 2007·Angewandte Chemie·Guido H CleverThomas Carell
Feb 5, 2009·Nucleic Acids Research·Jaroslav KyprMichaela Vorlícková
Nov 11, 2010·Nucleic Acids Research·Erik B PedersenVyacheslav V Filichev
Dec 3, 2010·Nature Chemistry·Silke JohannsenJens Müller
Jul 27, 2011·Chemical Society Reviews·Gavin W Collie, Gary N Parkinson
Sep 9, 2011·Chemical Society Reviews·Jungkweon Choi, Tetsuro Majima
Dec 15, 2012·Angewandte Chemie·Jean-Louis H A DupreyMitsuhiko Shionoya
Feb 9, 2013·Chemical Reviews·Osman DolucaVyacheslav V Filichev
Feb 21, 2013·Nature Chemistry·Giulia BiffiShankar Balasubramanian
Nov 28, 2013·Angewandte Chemie·David M EngelhardGuido H Clever
Apr 1, 1986·Journal of Computational Chemistry·Scott J WeinerDavid A Case

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Citations

Jul 2, 2019·Angewandte Chemie·Shuvankar NaskarJens Müller

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Methods Mentioned

BETA
electrophoresis

Software Mentioned

Schrödinger
AMBER
Macromodel®
Maestro®
Synergy

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