Towards Molecular Profiling in Multiple Myeloma: A Literature Review and Early Indications of Its Efficacy for Informing Treatment Strategies

International Journal of Molecular Sciences
Wolfgang WillenbacherSemir Vranic

Abstract

Multiple myeloma (MM), the second most common hematologic malignancy, is characterized by the clonal expansion of plasma cells. Despite dramatic improvements in patients' survival over the past decade due to advances in therapy exploiting novel molecular targets (immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies), the treatment of relapsed and refractory disease remains challenging. Recent studies confirmed complex, dynamic, and heterogeneous genomic alterations without unifying gene mutations in MM patients. In the current review, we survey recent therapeutic strategies, as well as molecular profiling data on MM, with emphasis on relapsed and refractory cases. A critical appraisal of novel findings and of their potential therapeutic implications will be discussed in detail, along with the author's own experiences/views.

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Citations

Jul 25, 2019·American Journal of Hematology·Irit AviviArtur Jurczyszyn
Feb 18, 2020·Molecular and Clinical Oncology·Muhamaad Naveed ShahzadChunlan Huang
Nov 9, 2018·International Journal of Molecular Sciences·Chia-Hung Yen, Hui-Hua Hsiao

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Methods Mentioned

BETA
chromosomal aberrations
ubiquitination
acetylation
pharmacotherapy

Clinical Trials Mentioned

NCT03416374
NCT02654990

Software Mentioned

SUMMIT
PROFILE
ENDEAVOR
ONCO
VISTA

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