Towards non-thrombogenic performance of blood recirculating devices.

Annals of Biomedical Engineering
D BluesteinK B Manning

Abstract

Implantable blood recirculating devices have provided life saving solutions to patients with severe cardiovascular diseases. However, common problems of hemolysis and thromboembolism remain an impediment to these devices. In this article, we present a brief review of the work by several groups in the field that has led to the development of new methodologies that may facilitate achieving the daunting goal of optimizing the thrombogenic performance of blood recirculating devices. The aim is to describe work which pertains to the interaction between flow-induced stresses and the blood constituents, and that supports the hypothesis that thromboembolism in prosthetic blood recirculating devices is initiated and maintained primarily by the non-physiological flow patterns and stresses that activate and enhance the aggregation of blood platelets, increasing the risk of thromboembolism and cardioembolic stroke. Such work includes state-of-the-art numerical and experimental tools used to elucidate flow-induced mechanisms leading to thromboembolism in prosthetic devices. Following the review, the paper describes several efforts conducted by some of the groups active in the field, and points to several directions that should be pursued in...Continue Reading

References

Mar 24, 1990·Lancet·J R O'Brien
Jan 1, 1990·Advances in Experimental Medicine and Biology·J R O'Brien, G P Salmon
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P A AartsR M Heethaar
Jan 1, 1987·Annals of the New York Academy of Sciences·E C EcksteinA W Tilles
May 1, 1987·Journal of Biomechanical Engineering·K A MannW S Pierce
Dec 10, 1970·The New England Journal of Medicine·L A Harker, S J Slichter
Jan 1, 1969·Medical & Biological Engineering·M Bluestein, L F Mockros
Feb 1, 1980·Science·V T Turitto, H J Weiss
Jul 1, 1993·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·T C LamsonJ M Tarbell
Jul 1, 1993·Artificial Organs·H SchimaE Wolner
Jul 1, 1995·Artificial Organs·C Bludszuweit
Jan 1, 1996·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D GeorgiadisK R Lees
Feb 1, 1996·Journal of Biomechanical Engineering·C S LeeL D Chen
Aug 1, 1996·Journal of Biomechanical Engineering·D BluesteinM K Dewanjee
Sep 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·G W BurgreenB P Griffith
Mar 1, 1997·Annals of Biomedical Engineering·T M HealyA P Yoganathan
Mar 1, 1997·Annals of Biomedical Engineering·D BluesteinM K Dewanjee
Jan 4, 1998·Journal of Biomechanical Engineering·C KirisI D Chang
Apr 20, 1999·Computers in Biology and Medicine·C B ReiningerL Schweiberer
Sep 1, 1999·Annals of Biomedical Engineering·E N SorensenJ F Antaki
Apr 28, 2000·Annals of Biomedical Engineering·D Bluestein
Jun 2, 2000·Journal of Biomechanical Engineering·D BluesteinM Gharib
Jun 10, 2000·Artificial Organs·C BachmannJ M Tarbell
Mar 27, 2001·The Annals of Thoracic Surgery·R D DowlingL A Gray
Mar 27, 2001·The Annals of Thoracic Surgery·A El-BanayosyK Minami
Jun 14, 2001·Artificial Organs·G W BurgreenA J Holmes
Jul 4, 2001·Medical Engineering & Physics·T DavidP G Walker
Sep 29, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J ApelH Reul
May 25, 2002·The International Journal of Artificial Organs·S KlausB Glasmacher
Dec 21, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Joachim LaasAiman Alken
Feb 22, 2003·Journal of Biomechanics·P Worth Longest, Clement Kleinstreuer

❮ Previous
Next ❯

Citations

Jan 30, 2013·Biomechanics and Modeling in Mechanobiology·João S SoaresDanny Bluestein
Jun 4, 2011·Annals of Biomedical Engineering·Alessandro Bellofiore, Nathan J Quinlan
Apr 19, 2012·Circulation. Cardiovascular Interventions·Jesse W RowleyUNKNOWN 2011 Platelet Colloquium Participants
May 25, 2010·The Journal of Thoracic and Cardiovascular Surgery·Didier LapeyreWalter Dembitsky
Mar 22, 2014·Artificial Organs·Alois PfennigerMagnus Jonsson
Jan 23, 2014·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Alison L MarsdenMarek Behr
Aug 19, 2014·International Journal for Numerical Methods in Biomedical Engineering·V ChivukulaS Vigmostad
Jun 29, 2016·Cardiovascular Engineering and Technology·Joshua O TaylorKeefe B Manning
Aug 16, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Costantino Del GaudioGiovanni Paolo Romano
Apr 4, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julio SoteloSergio Uribe
Apr 19, 2018·Circulation. Heart Failure·Venkat Keshav ChivukulaClaudius Mahr
Sep 13, 2013·Journal of Biomechanical Engineering·J GarciaL Kadem
Feb 7, 2019·Annals of Biomedical Engineering·Vi VuKaren May-Newman
Oct 12, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Thomas E ClaiborneDanny Bluestein
Jul 7, 2019·The International Journal of Artificial Organs·Christian LoosliPaolo Ermanni
Apr 20, 2014·The International Journal of Artificial Organs·Simon J SonntagUlrich Steinseifer
Mar 19, 2019·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Bente ThamsenMirko Meboldt
Apr 30, 2020·Artificial Organs·Giulia LuraghiFrancesco Migliavacca
Apr 2, 2020·Annals of Biomedical Engineering·Andreas EscherMarcus Granegger
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Massimo Capoccia
Dec 30, 2016·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Alberto AlisedaClaudius Mahr
Sep 20, 2018·Scientific Reports·Gabriel FuchsLisa Prahl Wittberg
Jun 27, 2019·Cardiovascular Engineering and Technology·Ewa Klusak, Nathan J Quinlan
Nov 22, 2020·International Journal for Numerical Methods in Biomedical Engineering·Felipe GalarceOlga Mula
Jul 21, 2021·Interactive Cardiovascular and Thoracic Surgery·Giorgio ViganoBart J Kooi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.