Towards nuclear magnetic resonance micro-spectroscopy and micro-imaging

The Analyst
P J M van BentumArno P M Kentgens

Abstract

The first successful experiments demonstrating Nuclear Magnetic Resonance (NMR) were a spin-off from the development of electromagnetic technology and its introduction into civilian life in the late forties. It was soon discovered that NMR spectra held chemically relevant information making it useful as an analytical tool. By introducing a new way of detection, moving away from continuous wave spectroscopy, Fourier Transform NMR helped to overcome sensitivity problems and subsequently opened the way for multi-dimensional spectroscopy. As a result NMR has developed into one of the most powerful analysis techniques with widespread applications. Still sensitivity is a limiting factor in the applicability of NMR. Therefore we witness a renaissance of technique development in magnetic resonance striving to improve its receptiveness. This tutorial review introduces the efforts currently made in miniaturizing inductive detection by designing optimal radio-frequency microcoils. A second approach is to introduce a new way of detecting magnetic resonance signals by means of very sensitive micromechanical force detectors. This shows that the detection limits in terms of absolute sensitivity or imaging resolution are still open to signific...Continue Reading

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Citations

Feb 24, 2005·Lab on a Chip·Henk WensinkAlbert van den Berg
Mar 12, 2011·Annual Review of Analytical Chemistry·Raluca M Fratila, Aldrik H Velders
Feb 2, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Franz DalitzGisela Guthausen
Oct 13, 2017·Physical Chemistry Chemical Physics : PCCP·Ying ChenNancy M Washton
Nov 25, 2017·The Analyst·I FugariuA J Simpson
Apr 29, 2006·Electrophoresis·Pertti J Viskari, James P Landers
Mar 14, 2019·Journal of the American Chemical Society·Anna Jo Oosthoek-de VriesArno P M Kentgens
Jul 21, 2006·The Journal of Physical Chemistry. B·K YamauchiT Asakura

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