Towards organogenesis and morphogenesis in vitro: harnessing engineered microenvironment and autonomous behaviors of pluripotent stem cells

Integrative Biology : Quantitative Biosciences From Nano to Macro
Ningwei LiYubing Sun

Abstract

Recently, researchers have been attempting to control pluripotent stem cell fate or generate self-organized tissues from stem cells. Advances in bioengineering enable generation of organotypic structures, which capture the cellular components, spatial cell organization and even some functions of tissues or organs in development. However, only a few engineering tools have been utilized to regulate the formation and organization of spatially complex tissues derived from stem cells. Here, we provide a review of recent progress in the culture of organotypic structures in vitro, focusing on how microengineering approaches including geometric confinement, extracellular matrix (ECM) property modulation, spatially controlled biochemical factors, and external forces, can be utilized to generate organotypic structures. Moreover, we will discuss potential technologies that can be applied to further control both soluble and insoluble factors spatiotemporally in vitro. In summary, advanced engineered approaches have a great promise in generating miniaturized tissues and organs in a reproducible fashion, facilitating the cellular and molecular understanding of embryogenesis and morphogenesis processes.

References

Oct 1, 1969·Journal of Theoretical Biology·L Wolpert
Mar 15, 1973·Experimental Cell Research·A Harris
Dec 1, 1972·Kybernetik·A Gierer, H Meinhardt
Oct 7, 1981·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L Wolpert
Apr 29, 1994·Science·R SinghviD E Ingber
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·John L TanChristopher S Chen
Apr 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·M P LutolfJ A Hubbell
Jun 21, 2005·Developmental Biology·Jiwang Zhang, Linheng Li
Jul 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Celeste M NelsonChristopher S Chen
Feb 7, 2006·Biomaterials·Didier FalconnetMarcus Textor
Jul 28, 2006·Nature·George M Whitesides
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Aug 16, 2008·Stem Cells·Sami Alom Ruiz, Christopher S Chen
Aug 30, 2008·Current Opinion in Genetics & Development·Carl-Philipp Heisenberg, Lilianna Solnica-Krezel
Apr 30, 2009·Annual Review of Biomedical Engineering·Deok-Ho KimYu Sun
Jun 6, 2009·Angewandte Chemie·Christopher J BettingerJeffrey T Borenstein
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·K R StevensC E Murry
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Deok-Ho KimAndre Levchenko
Jan 7, 2010·The Journal of Clinical Investigation·Raheem Peerani, Peter W Zandstra
Mar 9, 2010·Biomaterials·Yoon Young ChoiSang-Hoon Lee
Apr 15, 2010·Development·Tadanori Mammoto, Donald E Ingber
Jun 26, 2010·Science·Dongeun HuhDonald E Ingber
Jul 2, 2010·Annual Review of Cell and Developmental Biology·Albert J KeungDavid V Schaffer
Jul 19, 2008·Annual Review of Analytical Chemistry·Ivar Meyvantsson, David J Beebe
Oct 20, 2010·The Journal of Cell Biology·Amandine PitavalManuel Théry
Dec 3, 2010·Journal of Cell Science·Manuel Théry
Apr 9, 2011·Nature·Mototsugu EirakuYoshiki Sasai
Oct 13, 2011·Acta Biomaterialia·Peng-Yuan WangNicolas H Voelcker
Mar 13, 2012·Annual Review of Biophysics·Yubing SunJianping Fu
Apr 26, 2012·Nature Communications·Murat Guvendiren, Jason A Burdick
May 23, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Melissa A KinneyTodd C McDevitt
May 23, 2012·PloS One·Yubing SunJianping Fu
May 29, 2012·Cell·Tamako NishimuraMasatoshi Takeichi
Jun 14, 2012·Birth Defects Research. Part C, Embryo Today : Reviews·Matthew A WyczalkowskiLarry A Taber
Jun 19, 2012·Cell Stem Cell·Tokushige NakanoYoshiki Sasai
Aug 3, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Albert J KeungDavid V Schaffer
Aug 3, 2012·Cold Spring Harbor Perspectives in Biology·Jennifer Nichols, Austin Smith

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Citations

Jul 28, 2019·Current Opinion in Organ Transplantation·Ivan MartinNicolas C Rivron
Feb 17, 2019·International Journal of Molecular Sciences·Peter P NimiritskyPavel I Makarevich
May 25, 2021·Brain Research Bulletin·Aleeza Zilberman, R Chase Cornelison

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