Towards osteogenic and bactericidal nanopatterns?

Nanotechnology
Dwisetya S WidyaratihA A Zadpoor

Abstract

Recent discoveries have shown that nanopatterns with feature sizes ≤100 nm could direct stem cell fate or kill bacteria. These effects could be used to develop orthopedic implants with improved osseointegration and decreased chance of implant-associated infections. The quest for osteogenic and bactericidal nanopatterns is ongoing but no controlled nanopatterns with dual osteogenic and bactericidal functionalities have been found yet. In this study, electron beam induced deposition (EBID) was used for accurate and reproducible decoration of silicon surfaces with four different types of nanopatterns. The features used in the first two nanopatterns (OST1 and OST2) were derived from osteogenic nanopatterns known to induce osteogenic differentiation of stem cells in the absence of osteogenic supplements. Two modifications of these nanopatterns were also included (OST2-SQ, OST2-H90) to study the effects of controlled disorder and lower nanopillar heights. An E. coli K-12 strain was used for probing the response of bacteria to the nanopatterns. Three nanopatterns (OST2, OST2-SQ, and OST2-H90) exhibited clear bactericidal behavior as evidenced by severely damaged cells and disrupted formation of extracellular polymeric substance. These...Continue Reading

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Citations

Oct 19, 2019·Biomaterials Science·Amir A Zadpoor
Jul 11, 2020·Journal of Functional Biomaterials·Floris HonigLidy E Fratila-Apachitei
Dec 13, 2019·Scientific Reports·Mahya GanjianAmir A Zadpoor
Apr 8, 2021·Beilstein Journal of Nanotechnology·Cristiano GlessiMats Tilset
May 8, 2021·Acta Biomaterialia·Mae Jemison, Ronke Olabisi
Jun 21, 2021·Colloids and Surfaces. B, Biointerfaces·Qianqian CuiDan Ge
Sep 26, 2019·The Journal of Physical Chemistry. B·Tianqing LiuShui Guan

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