Towards personalized treatment of pain using a quantitative systems pharmacology approach

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Sebastiaan C GouloozeJ G Coen van Hasselt

Abstract

Pain is a complex biopsychosocial phenomenon of which the intensity, location and duration depends on various underlying components. Treatment of pain is associated with considerable inter-individual variability, and as such, requires a personalized approach. However, a priori prediction of optimal analgesic treatment for individual patients is still challenging. Another challenge is the assessment and treatment of pain in patients unable to self-report pain. In this mini-review, we first provide a brief overview of the various components underlying pain, and their associated biomarkers. These include clinical, psychosocial, neurophysiological, and biochemical components. We then discuss the use of empirical and mechanism-based pharmacokinetic-pharmacodynamic modelling to support personalized treatment of pain. Finally, we propose how these concepts can be extended to a quantitative systems pharmacology (QSP) approach that integrates the components of clinical pain and treatment response. This integrative approach can support predictions of optimal pharmacotherapy of pain, compared with approaches that focus on single components of pain. Moreover, combination of QSP modelling with state-of-the-art metabolomics approaches may of...Continue Reading

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Citations

Oct 30, 2018·Pharmacogenomics·Ismael A Rodríguez-RodríguezOmar González-Santiago
Jan 18, 2019·Expert Opinion on Drug Safety·Jagroop M ParikhVidya Chidambaran
Jan 10, 2020·Paediatric Drugs·Jean C DinhBridgette L Jones
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Feb 13, 2018·Expert Opinion on Drug Metabolism & Toxicology·Cornelis SmitCatherijne A J Knibbe
Nov 24, 2020·Bioinformatics·Giulia SimoniLuca Marchetti
Jan 25, 2018·Expert Opinion on Drug Metabolism & Toxicology·Tamara Van DongeKarel Allegaert
Aug 13, 2021·Journal of Clinical Pharmacology·Sebastiaan C GouloozeCatherijne A J Knibbe

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