Towards precision medicine in severe asthma: Treatment algorithms based on treatable traits

Respiratory Medicine
Andriana I PapaioannouStelios Loukides

Abstract

Asthma is a common disease, and although its clinical manifestations may be similar among patients, recent research discoveries have shown that it consists of several distinct clinical clusters or phenotypes, each with different underlying molecular pathways yielding different treatment responses. Based on these observations, an alternative approach - known as 'precision medicine' - has been proposed for the management of patients with severe asthma. Precision medicine advocates identification of treatable traits, linking them to therapeutic approaches targeting genetic, immunological, environmental, and/or lifestyle factors in individual patients. The main "goal" of this personalised approach is to enable choosing a treatment which will be more likely to produce a beneficial response in the individual patient rather than a 'one size fits all' approach. The aim of the present review is to discuss different ways of phenotyping asthma and to provide a rationale for treatment algorithms based on principles of precision medicine.

Citations

Jan 5, 2020·Expert Review of Respiratory Medicine·Diego BagnascoGiorgio Walter Canonica
Dec 20, 2019·Expert Review of Respiratory Medicine·Meghan Althoff, Fernando Holguin
Jan 24, 2019·BioMed Research International·Enrico HefflerAndrei Malinovschi
Sep 12, 2020·Yeungnam University Journal of Medicine·Hyun Jung Jin
May 29, 2021·Journal of Asthma and Allergy·Manisha RamphulErol A Gaillard
Jun 11, 2021·ERJ Open Research·Chris KyriakopoulosKonstantinos Kostikas
Nov 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Roland BuhlMonica Kraft

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