Towards precision medicine: Therapeutic drug monitoring-guided dosing of vancomycin and β-lactam antibiotics to maximize effectiveness and minimize toxicity.

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Jaclyn A CusumanoKerry L LaPlante

Abstract

The goal of this review is to explore the role of antimicrobial therapeutic drug monitoring (TDM), especially in critically ill, obese, and older adults, with a specific focus on β-lactams and vancomycin. The continued rise of antimicrobial resistance prompts the need to optimize antimicrobial dosing. The aim of TDM is to individualize antimicrobial dosing to achieve antibiotic exposures associated with improved patient outcomes. Initially, TDM was developed to minimize adverse effects during use of narrow therapeutic index agents. Today, patient and organism complexity are expanding the need for precision dosing through TDM services. Alterations of pharmacokinetics and pharmacodynamics (PK/PD) in the critically ill, obese, and older adult populations, in conjunction with declining organism susceptibility, complicate attainment of therapeutic targets. Over the last decade, antimicrobial TDM has expanded with the emergence of literature supporting β-lactam TDM and a shift from monitoring vancomycin trough concentrations to monitoring of the ratio of area under the concentration (AUC) curve to minimum inhibitory concentration (MIC). PK/PD experts should be at the forefront of implementing precision dosing practices. Precision dos...Continue Reading

References

Aug 1, 1990·Journal of Pharmaceutical Sciences·G B SmithA W Douglas
Jan 1, 1988·The Journal of Antimicrobial Chemotherapy·R WiseJ P Ashby
May 1, 1980·The Journal of Antimicrobial Chemotherapy·G N Rolinson
Mar 1, 1995·Antimicrobial Agents and Chemotherapy·D P NicolauR Quintiliani
Feb 10, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Sep 3, 2002·The Journal of Antimicrobial Chemotherapy·Vincent H TamGeorge L Drusano
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·D G MussonJ D Rogers
Mar 20, 2004·Nature Reviews. Microbiology·George L Drusano
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen M FaulknerJohn C Williamson
Aug 26, 2006·Diagnostic Microbiology and Infectious Disease·Christine T OngDavid P Nicolau
Sep 23, 2006·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·April D Miller, Kelly M Smith
Jan 30, 2008·Antimicrobial Agents and Chemotherapy·Thomas P LodiseG L Drusano
Dec 25, 2008·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael RybakDonald P Levine
Jul 10, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas P LodiseGeorge L Drusano
Dec 15, 2010·Clinical Pharmacokinetics·Marta UlldemolinsJeffrey Lipman
Dec 25, 2010·The American Journal of Medicine·Lindsey PritchardK Bruce Bayley
Sep 29, 2011·Antimicrobial Agents and Chemotherapy·John A BossoPatrick D Mauldin
Mar 14, 2012·European Journal of Clinical Pharmacology·Sepideh ElyasiAmirhooshang Mohammadpour
Oct 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joel M DulhuntyJeffrey Lipman
Jan 22, 2013·Antimicrobial Agents and Chemotherapy·Natasha E HolmesPaul D R Johnson
Oct 30, 2013·Antimicrobial Agents and Chemotherapy·Michael N NeelyThomas P Lodise
Jan 17, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jason A RobertsUNKNOWN DALI Study
Jan 21, 2014·The Journal of Antimicrobial Chemotherapy·Gloria WongJason A Roberts
Apr 26, 2014·The American Journal of the Medical Sciences·Carlos A AlvarezRonald G Hall
Apr 29, 2014·The Lancet Infectious Diseases·Jason A RobertsUNKNOWN International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the Europe
Jun 10, 2014·Advanced Drug Delivery Reviews·Manjunath P PaiThomas P Lodise
Aug 20, 2014·Infectious Diseases and Therapy·Joseph J CarrenoSusan L Davis
Jan 16, 2015·Clinical Practice·Mary MallappallilMoro O Salifu
Apr 9, 2015·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Janice RichardsonE Paul O'Donnell
Aug 15, 2015·International Journal of Antimicrobial Agents·Mieke CarlierJason A Roberts
Sep 2, 2015·Surgical Infections·Stephen W DaviesRobert G Sawyer
Mar 19, 2016·International Journal of Antimicrobial Agents·Abdulaziz S AlobaidJason A Roberts
Mar 31, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Humphries, J A Hindler
May 5, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A CharmillonC Pulcini
Jul 15, 2016·Clinical Microbiology Reviews·Mordechai GrupperDavid P Nicolau
Nov 20, 2016·The Journal of Antimicrobial Chemotherapy·David ReevesAlison Thomson

❮ Previous
Next ❯

Citations

Oct 18, 2020·Clinical Pharmacology and Therapeutics·Jasmine H HughesRon J Keizer
Feb 2, 2021·The Journal of Antimicrobial Chemotherapy·Sarah C J JorgensenBruce R Dalton
Nov 25, 2020·Antibiotics·Andrzej GórskiRyszard Międzybrodzki
Nov 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karina Sommerfeld-KlattaFranciszek K Główka
Feb 2, 2021·Clinical Pharmacology and Therapeutics·Silke GastineJoseph F Standing
Feb 11, 2021·Clinical Pharmacology and Therapeutics·Sebastian G WichaUNKNOWN International Society of Anti-Infective Pharmacology (ISAP), the PK/PD study group of the European Society of Clinical Micro
May 17, 2021·The Journal of Antimicrobial Chemotherapy·Sarah C J JorgensenBruce R Dalton
Jul 11, 2021·The Journal of Antimicrobial Chemotherapy·Bruce R DaltonSarah C J Jorgensen
Jan 29, 2022·Seminars in Respiratory and Critical Care Medicine·Yasmeen P Abouelhassan, David Nicolau

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of the Association of Physicians of India
R S Chandra, N A Kshirsagar
Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Anne-Grete MärtsonJan-Willem Alffenaar
© 2022 Meta ULC. All rights reserved