Towards Predicting Patient-Specific Flow-Diverter Treatment Outcomes for Bifurcation Aneurysms: From Implantation Rehearsal to Virtual Angiograms

Annals of Biomedical Engineering
Thomas PeachY Ventikos


Despite accounting for the majority of all cerebral aneurysm cases, bifurcation aneurysms present many challenges to standard endovascular treatment techniques. This study examines the treatment of bifurcation aneurysms endovascularly with flow-diverting stents and presents an integrative computational modeling suite allowing for rehearsing all aspects of the treatment. Six bifurcation aneurysms are virtually treated with 70% porosity flow-diverters. Substantial reduction (>50%) in aneurysm inflow due to device deployment is predicted in addition to reductions in peak and average aneurysm wall shear stress to values considered physiologically normal. The subsequent impact of flow-diverter deployment on daughter vessels that are jailed by the device is investigated further, with a number of simulations conducted with increased outlet pressure conditions at jailed vessels. Increased outlet pressures at jailed daughter vessels are found to have little effect on device-induced aneurysm inflow reduction, but large variation (13-86%) is seen in the resulting reduction in daughter vessel flow rate. Finally, we propose a potentially powerful approach for validation of such models, by introducing an angiographic contrast model, with con...Continue Reading


Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
Sep 3, 2004·Journal of Biomechanical Engineering·Gordon R Stuhne, D A Steinman
Dec 15, 2005·IEEE Transactions on Medical Imaging·Matthew D FordD A Steinman
Jan 20, 2009·Stroke; a Journal of Cerebral Circulation·Chander SadasivanBaruch B Lieber
Oct 5, 2010·Journal of Biomechanics·Maryam SaadatmandTakami Yamaguchi
Jan 15, 2011·Medical Engineering & Physics·Liang-Der Jou, Michel E Mawad
Apr 26, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·George K C WongW S Poon
Jul 12, 2012·Journal of Neurointerventional Surgery·Tim E DarsautJean Raymond
Jul 31, 2012·Journal of Clinical Monitoring and Computing·Philippe ReymondNikos Stergiopulos
Sep 29, 2012·AJNR. American Journal of Neuroradiology·I LarrabideA F Frangi
Nov 30, 2012·Computational and Mathematical Methods in Medicine·Jürgen EndresArnd Dörfler
Dec 15, 2012·European Journal of Radiology·S MangiaficoM Muto
Feb 12, 2013·Journal of Neurosurgery·Andrew K JohnsonDemetrius K Lopes
Apr 11, 2014·International Journal for Numerical Methods in Biomedical Engineering·Juan R CebralDavid Kallmes
Jun 24, 2014·IEEE Transactions on Bio-medical Engineering·K Spranger, Y Ventikos
Jul 22, 2014·International Journal for Numerical Methods in Biomedical Engineering·Thomas PeachY Ventikos
Aug 15, 2014·Neurosurgery·Suzana SalemeCharbel Mounayer
Nov 18, 2014·Cardiovascular Engineering and Technology·Thomas PeachY Ventikos
Dec 15, 2015·Computer Methods in Applied Mechanics and Engineering·K SprangerY Ventikos


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