Towards rational use of antibiotics for suspected secondary infections in Buruli ulcer patients

PLoS Neglected Tropical Diseases
Yves T BaroguiYmkje Stienstra

Abstract

The emerging disease Buruli ulcer is treated with streptomycin and rifampicin and surgery if necessary. Frequently other antibiotics are used during treatment. Information on prescribing behavior of antibiotics for suspected secondary infections and for prophylactic use was collected retrospectively. Of 185 patients that started treatment for Buruli ulcer in different centers in Ghana and Bénin 51 were admitted. Forty of these 51 admitted patients (78%) received at least one course of antibiotics other than streptomycin and rifampicin during their hospital stay. The median number (IQR) of antibiotic courses for admitted patients was 2 (1, 5). Only twelve patients received antibiotics for a suspected secondary infection, all other courses were prescribed as prophylaxis of secondary infections extended till 10 days on average after excision, debridement or skin grafting. Antibiotic regimens varied considerably per indication. In another group of BU patients in two centers in Bénin, superficial wound cultures were performed. These cultures from superficial swabs represented bacteria to be expected from a chronic wound, but 13 of the 34 (38%) S. aureus were MRSA. A guide for rational antibiotic treatment for suspected secondary inf...Continue Reading

References

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Related Concepts

Vancomycin
Microorganism
Enterobacteriaceae
Necrosis
Antibiogram
Pseudomonas aeruginosa (antigen)
Ceftriaxone
Nodule
Physiologic Warmth
Amoxicillin

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