Towards scaling Twitter for digital epidemiology of birth defects

NPJ Digital Medicine
Ari KleinGraciela Gonzalez-Hernandez

Abstract

Social media has recently been used to identify and study a small cohort of Twitter users whose pregnancies with birth defect outcomes-the leading cause of infant mortality-could be observed via their publicly available tweets. In this study, we exploit social media on a larger scale by developing natural language processing (NLP) methods to automatically detect, among thousands of users, a cohort of mothers reporting that their child has a birth defect. We used 22,999 annotated tweets to train and evaluate supervised machine learning algorithms-feature-engineered and deep learning-based classifiers-that automatically distinguish tweets referring to the user's pregnancy outcome from tweets that merely mention birth defects. Because 90% of the tweets merely mention birth defects, we experimented with under-sampling and over-sampling approaches to address this class imbalance. An SVM classifier achieved the best performance for the two positive classes: an F1-score of 0.65 for the "defect" class and 0.51 for the "possible defect" class. We deployed the classifier on 20,457 unlabeled tweets that mention birth defects, which helped identify 542 additional users for potential inclusion in our cohort. Contributions of this study incl...Continue Reading

References

Oct 23, 1997·Neural Computation·S Hochreiter, J Schmidhuber
Mar 9, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Dianne L KennedySandra L Kweder
Oct 6, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Quanhe YangMargaret A Honein
Oct 20, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Angela E LinMarlene Anderka
Sep 25, 2008·PloS One·Yasser El-ManzalawyVasant Honavar
Mar 26, 2009·American Journal of Obstetrics and Gynecology·Teri PearlsteinCaron Zlotnick
Jan 15, 2013·Women's Health Issues : Official Publication of the Jacobs Institute of Women's Health·Mary C BleharJanine A Clayton
Dec 3, 2014·Journal of Biomedical Informatics·Abeed Sarker, Graciela Gonzalez
Nov 28, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Cara T MaiUNKNOWN National Birth Defects Prevention Network
Jan 11, 2016·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Abeed SarkerGraciela Gonzalez
Jun 7, 2016·Clinics in Dermatology·Rebecca I Hartman, Alexa B Kimball
Feb 22, 2017·Obstetrical & Gynecological Survey·Benjamin S HarrisJeffrey A Kuller
Jun 1, 2017·BMJ : British Medical Journal·Marcia L FeldkampLorenzo D Botto
Nov 1, 2017·Journal of Medical Internet Research·Abeed SarkerGraciela Gonzalez
Aug 10, 2018·Neural Networks : the Official Journal of the International Neural Network Society·Mateusz BudaMaciej A Mazurowski
Oct 3, 2018·Journal of the American Medical Informatics Association : JAMIA·Abeed SarkerGraciela Gonzalez-Hernandez
Oct 5, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Su GolderGraciela Gonzalez-Hernandez
Nov 18, 2018·Journal of Biomedical Informatics·Abeed Sarker, Graciela Gonzalez-Hernandez

❮ Previous
Next ❯

Citations

Jan 26, 2021·Clinical Pharmacology and Therapeutics·Adam LavertuStefano Rensi
Jan 1, 2020·Journal of Biomedical Informatics·Ari Z KleinGraciela Gonzalez-Hernandez

❮ Previous
Next ❯

Software Mentioned

TensorFlow
LibSVM
SMOTE
Keras
Weka
WLSVM Weka
PTBTokenizer

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.