Towards specific NADPH oxidase inhibition by small synthetic peptides.

Cellular and Molecular Life Sciences : CMLS
Jamel El-BennaAxel Périanin

Abstract

Reactive oxygen species (ROS) production by the phagocyte NADPH oxidase is essential for host defenses against pathogens. ROS are very reactive with biological molecules such as lipids, proteins and DNA, potentially resulting in cell dysfunction and tissue insult. Excessive NADPH oxidase activation and ROS overproduction are believed to participate in disorders such as joint, lung, vascular and intestinal inflammation. NADPH oxidase is a complex enzyme composed of six proteins: gp91phox (renamed NOX2), p22phox, p47phox, p67phox, p40phox and Rac1/2. Inhibitors of this enzyme could be beneficial, by limiting ROS production and inappropriate inflammation. A few small non-peptide inhibitors of NADPH oxidase are currently used to inhibit ROS production, but they lack specificity as they inhibit NADPH oxidase homologues or other unrelated enzymes. Peptide inhibitors that target a specific sequence of NADPH oxidase components could be more specific than small molecules. Here we review peptide-based inhibitors, with particular focus on a molecule derived from gp91phox/NOX2 and p47phox, and discuss their possible use as specific phagocyte NADPH oxidase inhibitors.

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Citations

Jun 20, 2013·Cardiovascular Diabetology·Hong LiChuanshi Xiao
Aug 29, 2013·Vascular Health and Risk Management·Bruno K Rodiño-JaneiroEzequiel Alvarez
Sep 28, 2013·Antioxidants & Redox Signaling·Eugenia Cifuentes-PaganoPatrick J Pagano
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Jan 5, 2014·Antioxidants & Redox Signaling·Joanna WieczfinskaRafal Pawliczak
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Feb 22, 2013·Circulation·Sanjana DayalSteven R Lentz
Dec 6, 2014·Current Rheumatology Reports·Sonsoles Piera-Velazquez, Sergio A Jimenez

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