Towards tailored radiopeptide therapy

European Journal of Nuclear Medicine and Molecular Imaging
Piotr RadojewskiMartin A Walter

Abstract

Somatostatin receptor-targeted radiopeptide therapy is commonly performed using single radioisotopes. We evaluated the benefits and harms of combining radioisotopes in radiopeptide therapy in patients with neuroendocrine tumor. Using multivariable-adjusted survival analyses and competing risk analyses we evaluated outcomes in patients with neuroendocrine tumor receiving (90)Y-DOTATOC, (177)Lu-DOTATOC or their combination. (90)Y-DOTATOC plus (177)Lu-DOTATOC treatment was associated with longer survival than (90)Y-DOTATOC (66.1 vs. 47.5 months; n = 1,358; p < 0.001) or (177)Lu-DOTATOC alone (66.1 vs. 45.5 months; n = 390; p < 0.001). (177)Lu-DOTATOC was associated with longer survival than (90)Y-DOTATOC in patients with solitary lesions (HR 0.3, range 0.1 - 0.7; n = 153; p = 0.005), extrahepatic metastases (HR 0.5, range 0.3 - 0.9; n = 256; p = 0.029) and metastases with low uptake (HR 0.1, range 0.05 - 0.4; n = 113; p = 0.001). (90)Y-DOTATOC induced higher hematotoxicity rates than combined treatment (9.5% vs. 4.0%, p = 0.005) or (177)Lu-DOTATOC (9.5 vs. 1.4%, p = 0.002). Renal toxicity was similar among the treatments. Using (90)Y and (177)Lu might facilitate tailoring radiopeptide therapy and improve survival in patients with ...Continue Reading

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Citations

Aug 25, 2016·Seminars in Nuclear Medicine·Belkis Erbas, Murat Tuncel
Jan 8, 2017·EJNMMI Physics·Carlos F UribeAnna Celler
May 27, 2016·Biomarkers in Cancer·Katherine ZukotynskiFrederic Fahey
Aug 14, 2018·The British Journal of Radiology·Deborah PencharzShaunak Navalkissoor
Sep 8, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Samuel AdantJean-Mathieu Beauregard
Jan 26, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Jolanta KunikowskaLeszek Królicki
Oct 31, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Kristell L S ChatalicMarion de Jong
Aug 28, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Clemens KratochwilAlfred Morgenstern

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