Towards the electrospray ionization mass spectrometry ionization efficiency scale of organic compounds

Rapid Communications in Mass Spectrometry : RCM
Ivo LeitoRisto Tanner

Abstract

An approach that allows setting up under predefined ionization conditions a rugged self-consistent quantitative experimental scale of electrospray ionization (ESI) efficiencies of organic compounds is presented. By ESI ionization efficiency (IE) we mean the efficiency of generating gas-phase ions from analyte molecules or ions in the ESI source. The approach is based on measurement of relative ionization efficiency (RIE) of two compounds (B1 and B2) by infusing a solution containing both compounds at known concentrations (C1 and C2) and measuring the mass-spectrometric responses of the protonated forms of the compounds (R1 and R2). The RIE of B1 and B2 is expressed as logRIE(B1, B2) = log[(R1 . C2)/(C1 . R2)]. The relative way of measurement leads to cancellation of many of the factors affecting IE (ESI source design, voltages in the source and ion transport system, solvent composition, flow rates and temperatures of the nebulizing and drying gases). Using this approach an ESI IE scale containing ten compounds (esters and aromatic amines) and spanning over 4 logRIE units has been compiled. The consistency of the scale (the consistency standard deviation of the scale is s = 0.16 logRIE units) was assured by making measurements u...Continue Reading

Citations

Jun 13, 2013·Environmental Science & Technology·Junho JeonJuliane Hollender
Aug 11, 2012·Bioanalysis·Stephen W HolmanClaire E Eyers
May 23, 2012·International Journal of Analytical Chemistry·Shibdas Banerjee, Shyamalava Mazumdar
Aug 22, 2014·Journal of the American Society for Mass Spectrometry·Jaanus LiigandRodolphe Antoine
Oct 10, 2015·Angewandte Chemie·Shibdas Banerjee, Richard N Zare
Mar 5, 2016·Analytical Chemistry·Riin RebaneIvo Leito
Oct 27, 2009·Chemistry : a European Journal·Julia E Fleckenstein, Konrad Koszinowski
Mar 21, 2012·Journal of Mass Spectrometry : JMS·Signe VahurIvari Kaljurand
Jun 1, 2013·Journal of Mass Spectrometry : JMS·Anneli KruveIvo Leito
Oct 11, 2014·Journal of Mass Spectrometry : JMS·Anu TeearuLauri Toom
Aug 8, 2015·Journal of the American Society for Mass Spectrometry·Jaanus LiigandIvo Leito
Oct 16, 2015·Rapid Communications in Mass Spectrometry : RCM·Varvara J MandraCatherine K Markopoulou
Apr 5, 2016·Journal of the American Society for Mass Spectrometry·Piia LiigandAnneli Kruve
Feb 19, 2014·The Journal of Organic Chemistry·Sandip A KadamIvo Leito
Jul 16, 2013·The Journal of Organic Chemistry·Kristjan HaavIvo Leito
Dec 15, 2016·Journal of the American Society for Mass Spectrometry·Jaanus LiigandAnneli Kruve
Nov 30, 2016·Journal of the American Society for Mass Spectrometry·Arnaud LubinFilip Cuyckens
Nov 16, 2018·Rapid Communications in Mass Spectrometry : RCM·Jaanus LiigandFilip Cuyckens
Aug 6, 2019·Rapid Communications in Mass Spectrometry : RCM·Riin RebaneIvo Leito
Dec 14, 2019·Rapid Communications in Mass Spectrometry : RCM·J Michael Sutton, Michael G Bartlett
Mar 12, 2010·Analytical Chemistry·Merit OssIvo Leito
Aug 7, 2021·Rapid Communications in Mass Spectrometry : RCM·Merit OssIvo Leito

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