Towards the physical basis of how intrinsic disorder mediates protein function

Archives of Biochemistry and Biophysics
Jianhan Chen

Abstract

Intrinsically disordered proteins (IDPs) are an important class of functional proteins that is highly prevalent in biology and has broad association with human diseases. In contrast to structured proteins, free IDPs exist as heterogeneous and dynamical conformational ensembles under physiological conditions. Many concepts have been discussed on how such intrinsic disorder may provide crucial functional advantages, particularly in cellular signaling and regulation. Establishing the physical basis of these proposed phenomena requires not only detailed characterization of the disordered conformational ensembles, but also mechanistic understanding of the roles of various ensemble properties in IDP interaction and regulation. Here, we review the experimental and computational approaches that may be integrated to address many important challenges of establishing a "structural" basis of IDP function, and discuss some of the key emerging ideas on how the conformational ensembles of IDPs may mediate function, especially in coupled binding and folding interactions.

References

Dec 13, 1991·Science·H FrauenfelderP G Wolynes
Jan 1, 1983·Annual Review of Biophysics and Bioengineering·N Go
May 23, 2002·Biochemistry·A Keith DunkerZoran Obradović
Dec 14, 2002·Science·Maria M Garcia-MiraVictor Muñoz
Feb 11, 2003·Trends in Biochemical Sciences·Kannan GunasekaranRuth Nussinov
Jul 23, 2004·The Journal of Chemical Physics·Gerhard Hummer
Aug 2, 2005·Trends in Biochemical Sciences·Peter TompaLászló Buday
Sep 13, 2005·Structure·Bin Y QinKai Lin
Nov 4, 2005·Nature·Elan Z EisenmesserDorothee Kern
Sep 16, 2006·Science·David D BoehrPeter E Wright
Aug 31, 2007·Science·M Shirts, V S Pande
Dec 7, 2007·Trends in Biochemical Sciences·Peter Tompa, Monika Fuxreiter
Jan 10, 2008·Physical Chemistry Chemical Physics : PCCP·Jianhan Chen, Charles L Brooks
Feb 23, 2008·Journal of Computational Chemistry·Thenmalarchelvi Rathinavelan, Wonpil Im
Apr 12, 2008·PLoS Computational Biology·Adrian Gustavo TurjanskiGerhard Hummer
Apr 11, 2009·Science·Robert G Smock, Lila M Gierasch
Jun 15, 2010·Trends in Biochemical Sciences·Peter CsermelyRuth Nussinov
Aug 31, 2011·PLoS Computational Biology·Iskra Staneva, Stefan Wallin
Sep 16, 2011·Molecular BioSystems·Mátyás PajkosZsuzsanna Dosztányi
Sep 20, 2011·Molecular BioSystems·Monika Fuxreiter
Oct 29, 2011·Science·Kresten Lindorff-LarsenDavid E Shaw
Nov 15, 2011·Molecular BioSystems·Vladimir Vacic, Lilia M Iakoucheva
Nov 26, 2011·Molecular BioSystems·M Madan Babu
Dec 14, 2011·Structure·Sanbo QinHuan-Xiang Zhou
Dec 14, 2011·Trends in Biochemical Sciences·Huan-Xiang Zhou

❮ Previous
Next ❯

Citations

Mar 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Linda FoitJames C A Bardwell
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yong WangJin Wang
Feb 19, 2013·The Journal of Endocrinology·Rebecca McGirrSavita Dhanvantari
Dec 5, 2015·Journal of Chemical Theory and Computation·Trang Nhu DoMikko Karttunen
Mar 8, 2013·Current Opinion in Structural Biology·Domenico Cozzetto, David T Jones
Dec 26, 2012·Archives of Biochemistry and Biophysics·Bruno Rizzuti, Valerie Daggett
Sep 29, 2012·Trends in Biochemical Sciences·James C A Bardwell, Ursula Jakob
Jul 19, 2014·Biochimica Et Biophysica Acta·Takao Furuki, Minoru Sakurai
Jun 25, 2013·Molecular Reproduction and Development·Valérie VergéGérard Peaucellier
Oct 22, 2015·Biophysical Journal·Jianhan Chen
Sep 4, 2015·Biophysical Journal·Xiaorong LiuJianhan Chen
Jan 15, 2013·Journal of Molecular Biology·Chester McDowellJianhan Chen
Sep 16, 2014·Biochimica Et Biophysica Acta·Sara PellegrinoStefano Bettati
May 23, 2015·Scientific Reports·Yassmine ChebaroDavid J Wales
Jul 6, 2014·Journal of Computational Chemistry·Weihong Zhang, Jianhan Chen
Dec 30, 2014·Current Opinion in Structural Biology·Tao ChenHue Sun Chan
Dec 1, 2017·Physical Chemistry Chemical Physics : PCCP·Xiaorong Liu, Jianhan Chen
Mar 22, 2013·Journal of Physics. Condensed Matter : an Institute of Physics Journal·L Olivares-Quiroz
Mar 1, 2019·Biomolecules·Wenning Wang, Dongdong Wang
May 15, 2020·Biomolecules·Jianlin ChenJianhan Chen
Sep 19, 2013·Intrinsically Disordered Proteins·Trevor P Creamer
Jun 9, 2015·Journal of Computational Chemistry·Kuo Hao Lee, Jianhan Chen
Dec 11, 2020·Journal of Computational Chemistry·Xiaorong LiuJianhan Chen
Dec 24, 2020·Physical Chemistry Chemical Physics : PCCP·Wenning Wang
May 1, 2014·Wiley Interdisciplinary Reviews. Computational Molecular Science·Christopher M Baker, Robert B Best
Apr 30, 2015·Environmental Science & Technology·Mathias F GruberClaus Hélix-Nielsen
Sep 6, 2012·Biochemistry·Indrani DasguptaIris Lindberg
Jun 6, 2014·Chemical Reviews·Francois-Xavier TheilletPhilipp Selenko
Oct 30, 2014·Analytical Chemistry·Rebecca BeveridgePerdita E Barran
Nov 20, 2015·Journal of Chemical Theory and Computation·Trang Nhu DoMikko Karttunen
Sep 15, 2017·The Journal of Physical Chemistry. B·Xiaorong LiuJianhan Chen
Jun 11, 2013·Journal of Chemical Theory and Computation·Weihong Zhang, Jianhan Chen
Dec 5, 2012·The Journal of Physical Chemistry. B·Jeetain MittalThomas M Truskett
Jan 15, 2014·The Journal of Physical Chemistry. B·K Aurelia BallTeresa Head-Gordon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.