Towards the structure-based design of oligonucleotide therapeutics

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

Towards the structure-based design of oligonucleotide therapeutics

Abstract

References

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

Nucleoside phosphorothioates

Ordered water structure around a B-DNA dodecamer. A quantitative study

Structure of a B-DNA dodecamer. III. Geometry of hydration

A single 2'-hydroxyl group converts B-DNA to A-DNA. Crystal structure of the DNA-RNA chimeric decamer duplex d(CCGGC)r(G)d(CCGG) with a novel intermolecular G-C base-paired quadruplet

Site and mechanism of antisense inhibition by C-5 propyne oligonucleotides

Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

Oligonucleotide N3'-->P5' phosphoramidates

Backbone modifications in oligonucleotides and peptide nucleic acid systems

Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance.

Rapid crystallization of chemically synthesized hammerhead RNAs using a double screening procedure

Absorption, tissue distribution and in vivo stability in rats of a hybrid antisense oligonucleotide following oral administration

Phosphorodithioate DNA as a potential therapeutic drug

Conformational influence of the ribose 2'-hydroxyl group: crystal structures of DNA-RNA chimeric duplexes

Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines

Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes

PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules

The crystal structure of r(CCCCGGGG) in two distinct lattices

Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone

Current concepts in antisense drug design

Crystallization of ribozymes and small RNA motifs by a sparse matrix approach

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

An oligodeoxyribonucleotide N3'--> P5' phosphoramidate duplex forms an A-type helix in solution

RNA hydration: a detailed look

Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties

Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors

The structure of an RNA/DNA hybrid: a substrate of the ribonuclease activity of HIV-1 reverse transcriptase

2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides

Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo

Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids

Structural RNA mimetics: N3'-->P5' phosphoramidate DNA analogs of HIV-1 RRE and TAR RNA form A-type helices that bind specifically to Rev and Tat-related peptides

RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates

Stability of stereoregular oligo(nucleoside phosphorothioate)s in human plasma: diastereoselectivity of plasma 3'-exonuclease

In vivo studies with antisense oligonucleotides

2'-O-(2-Methoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level and inhibit formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells.

Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems

Antisense '97: a roundtable on the state of the industry

The influence of antisense oligonucleotide-induced RNA structure on Escherichia coli RNase H1 activity.

Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence

The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

Stabilizing effects of the RNA 2'-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2'-O-methylated adenosines

A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments

Synthesis and Structure of 1-Deoxy-1-phenyl-beta-D-ribofuranose and Its Incorporation into Oligonucleotides

Use of low-molecular-weight polyethylene glycol in the crystallization of RNA oligomers

Crystallization and preliminary X-ray diffraction analysis of double-helical RNA octamers

Pharmacology of antisense therapeutic agents : cancer and inflamination

Citations

Stabilizing contributions of sulfur-modified nucleotides: crystal structure of a DNA duplex with 2'-O-[2-(methoxy)ethyl]-2-thiothymidines

Insights from crystallographic studies into the structural and pairing properties of nucleic acid analogs and chemically modified DNA and RNA oligonucleotides

New method for the preparation of 3'- and 2'-O-phosphoramidites of 2'- and 3'-difluoromethyluridine derivatives

Factors influencing the steroid profile in doping control analysis

Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.

Related Concepts

Related Feeds

Antisense Oligonucleotides: ND

Related Papers

2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects

The long and winding road to the structure of homo-DNA

Obituary: Jacques H. van Boom (1937-2004)

Crystal structure of an RNA duplex containing phenyl-ribonucleotides, hydrophobic isosteres of the natural pyrimidines

Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues