Towards unconstrained compartment modeling in white matter using diffusion-relaxation MRI with tensor-valued diffusion encoding

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Björn LampinenMarkus Nilsson

Abstract

To optimize diffusion-relaxation MRI with tensor-valued diffusion encoding for precise estimation of compartment-specific fractions, diffusivities, and T2 values within a two-compartment model of white matter, and to explore the approach in vivo. Sampling protocols featuring different b-values (b), b-tensor shapes (bΔ ), and echo times (TE) were optimized using Cramér-Rao lower bounds (CRLB). Whole-brain data were acquired in children, adults, and elderly with white matter lesions. Compartment fractions, diffusivities, and T2 values were estimated in a model featuring two microstructural compartments represented by a "stick" and a "zeppelin." Precise parameter estimates were enabled by sampling protocols featuring seven or more "shells" with unique b/bΔ /TE-combinations. Acquisition times were approximately 15 minutes. In white matter of adults, the "stick" compartment had a fraction of approximately 0.5 and, compared with the "zeppelin" compartment, featured lower isotropic diffusivities (0.6 vs. 1.3 μm2 /ms) but higher T2 values (85 vs. 65 ms). Children featured lower "stick" fractions (0.4). White matter lesions exhibited high "zeppelin" isotropic diffusivities (1.7 μm2 /ms) and T2 values (150 ms). Diffusion-relaxation MRI w...Continue Reading

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Citations

Oct 7, 2020·Human Brain Mapping·João P de Almeida MartinsDaniel Topgaard
Dec 11, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexis ReymbautDaniel Topgaard
Nov 5, 2020·Journal of Neuroscience Methods·Rafael N HenriquesAndrada Ianuş
Nov 27, 2020·Journal of Neuroscience Methods·Filip SzczepankiewiczMarkus Nilsson
Oct 24, 2020·Journal of Neuroscience Methods·Dmitry S Novikov
Mar 23, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ilana R LeppertChristine L Tardif
Jul 22, 2020·Journal of Neuroscience Methods·Ileana O JelescuKurt G Schilling
Apr 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gabriel Ramos-LlordénYogesh Rathi
Aug 20, 2020·Journal of Neuroscience Methods·Kouhei KamiyaShigeki Aoki
Jun 1, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Markus NilssonFredrik Jäderling
Aug 20, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorJana Hutter
Jul 2, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yang JiLipeng Ning

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