Towards understanding the roles of position and geometry on cell fate decisions during preimplantation development

Seminars in Cell & Developmental Biology
John S BigginsShankar Srinivas

Abstract

The first lineage segregation event in mouse embryos produces two separate cell populations: inner cell mass and trophectoderm. This is understood to be brought about by cells sensing their position within the embryo and differentiating accordingly. The cellular and molecular underpinnings of this process remain under investigation and have variously been considered to be completely stochastic or alternately, subject to some predisposition set up at fertilisation or before. Here, we consider these views in light of recent publications, discuss the possible role of cell geometry and mechanical forces in this process and describe how modelling could contribute in addressing this issue.

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Citations

Oct 14, 2016·Stem Cells and Development·Maurizio PesceAntonio Paolo Beltrami
Jul 17, 2020·Frontiers in Cell and Developmental Biology·Roberto GaetaniElisa Messina
Jul 7, 2017·Biology of the Cell·Jean-Léon Maître
Sep 30, 2021·Cell and Tissue Research·Ecem YildirimAylin Yaba

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Methods Mentioned

BETA
FRET
single-cell sequencing

Software Mentioned

LifeAct

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