PMID: 9426185Jan 13, 1998Paper

Toxic and signaling effects of photochemically or chemically generated singlet oxygen in biological systems

Biological Chemistry
K BrivibaHelmut Sies

Abstract

Singlet oxygen, generated photochemically or chemically, has damaging effects on biomolecules and exerts genotoxic, virucidal and cytotoxic effects. This is of relevance for biological systems because singlet oxygen can be produced photochemically as a result of the irradiation of endogenous or exogenously applied photosensitizers with visible or ultraviolet light, or in dark reactions, e.g. by stimulated phagocytes during the so-called oxidative burst. In addition, there is increasing evidence that singlet oxygen has pronounced effects on cellular signaling events leading to the induced expression of a variety of proteins. A novel observation is the activation of transcription factor AP-2 and cellular signaling cascades comprising the activation of c-Jun-N-terminal kinases (JNK/SAPK) and the NF-kappaB system.

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Lars-Oliver KlotzHelmut Sies
Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne
Adriana Gabriela FilipSimina Dreve
Experimental Dermatology
Johannes RegensburgerWolfgang Bäumler
© 2021 Meta ULC. All rights reserved