Toxic chemicals and thyroid function: hard facts and lateral thinking

Reviews in Endocrine & Metabolic Disorders
Leonidas H Duntas, Nikos Stathatos

Abstract

Increasing quantities of evidence-based data incriminate a large number of environmental pollutants for toxic effects on the thyroid. Among the many chemical contaminants, halogenated organochlorines and pesticides variably affect the hypothalamic-pituitary-thyroid axis and disrupt thyroid function. PCBs and their metabolites and PBDEs bind to thyroid transport proteins, such as transthyretin, displace thyroxine, and disrupt thyroid function. Meanwhile, at the molecular level, PCB congeners may activate phosphorylation of Akt, p-Akt, and forkhead box O3a (FoxO3a) protein resulting in inhibition of the natrium/iodide symporter. Given therefore the growing concern developing around these multiple toxic chemicals today invading numerous environments and their long-term deleterious effects not only on the thyroid but also on general health, we strongly advocate their strict regulation and, moreover, their gradual reduction. A good degree of "lateral thinking", we feel, will lead to a use of chemicals that will enhance life while concurrently carefully protecting the environment.

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Citations

Aug 2, 2016·The Journal of Pediatrics·Yudan Wei, Jianmin Zhu
Aug 16, 2016·Reviews in Endocrine & Metabolic Disorders·Patricia Joseph-BravoJean-Louis Charli
Dec 19, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jennifer H OlkerMichael W Hornung
Dec 1, 2019·The Journal of Clinical Endocrinology and Metabolism·Sara Salehi HammerstadYaron Tomer
Sep 9, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·Li WangYu Duan
Apr 5, 2017·Frontiers in Endocrinology·Silvia Martina FerrariSalvatore Benvenga
Nov 21, 2018·Reviews in Endocrine & Metabolic Disorders·Roberto VitaSalvatore Benvenga
Dec 8, 2017·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Tayane C R MesquitaGevany P Pinho
Nov 30, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sunny Lihua ChengJulia Yue Cui
Jul 12, 2019·Frontiers in Endocrinology·Adair Rodríguez-RodríguezJean-Louis Charli

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