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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

Science

Apr 29, 1988

James A ImlayStuart Linn

Abstract

Exposure of Escherichia coli to low concentrations of hydrogen peroxide results in DNA damage that causes mutagenesis and kills the bacteria, whereas higher concentrations of peroxide reduce the amount of such damage. Earlier studies indicated that the direct DNA oxidant is a derivative...read more

Mentioned in this Paper

Metabolic Process, Cellular
Hydrogen Peroxide
Alkalescens-Dispar Group
Hydroxyl Radical
Perhydrol
Base Excision Repair
Bacteriophages
Free Radicals
Visual Suppression
Hydroxides
321
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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

Science

Apr 29, 1988

James A ImlayStuart Linn

PMID: 2834821

DOI: 10.1126/science.2834821

Abstract

Exposure of Escherichia coli to low concentrations of hydrogen peroxide results in DNA damage that causes mutagenesis and kills the bacteria, whereas higher concentrations of peroxide reduce the amount of such damage. Earlier studies indicated that the direct DNA oxidant is a derivative...read more

Mentioned in this Paper

Metabolic Process, Cellular
Hydrogen Peroxide
Alkalescens-Dispar Group
Hydroxyl Radical
Perhydrol
Base Excision Repair
Bacteriophages
Free Radicals
Visual Suppression
Hydroxides
321

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  • Citations613
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