Toxic effects and foundation of proton radiation on the early-life stage of zebrafish development

Chemosphere
Xiaoman LiBaoquan Zhao

Abstract

Proton is a major particle of space radiation environment and a prospective radiotherapy beam. However, its risk needs to be fully evaluated for the understanding and to establish the better protective strategy for astronaut and patient. Zebrafish is an ideal model for the toxicity studies on medicines and environmental genetic toxicants. In the current study, embryos of zebrafish at 24 h post-fertilization (hpf) were exposed to proton beam. Some toxic parameters of embryo-larval development were investigated. Microarray combining with qRT-PCR were used to detect the gene expression situation. Generally, fractions of a variety of abnormal phenotypes of embryos and larvae increased in a dose-dependent manner after irradiation. The copy number of mitochondria, the basal respiration rate and the maximum respiration rate of embryos significantly decreased after irradiation. Microarray data demonstrated that MAPK signaling pathway, cell communication, glycolysis and TGF-β signaling pathway were significantly affected in the irradiated group. The expressions of matrix metallopeptidase 9 (mmp9) and TIMP metallopeptidase inhibitor 2b (timp2b) genes, and enzymatic activity of MMP9 were significantly upregulated in irradiated group. Over...Continue Reading

Citations

Nov 9, 2018·PloS One·Emília Rita SzabóElke Beyreuther
Nov 13, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Lu GanHong Zhang
Dec 28, 2019·International Journal of Molecular Sciences·Juliette ThariatFrançois Chevalier
Jul 16, 2019·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Fernanda Fernandes CruzFernanda Bueno Morrone
Aug 28, 2021·Cancers·Theresa SuckertElke Beyreuther

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