Toxic Effects in Siganus oramin by dietary exposure to 4-tert-octylphenol

Bulletin of Environmental Contamination and Toxicology
Y B DuZ W Sun

Abstract

The integrated toxicities of 4-tert-octylphenol (t-OP) on Siganus oramin were investigated by dietary administration at doses of 5, 25 and 125 mg/kg body weight over 28 days. Significant increase was observed in the activity of hepatic glutathione S-transferase at 125 mg/kg on both day 14 and 28 in males, and at all doses on day 28 in females, and in hepatosomatic index at 25 mg/kg on day 14 in both sexes. Plasma levels of testosterone and cortisol decreased significantly at all doses on day 28. Histopathologic changes in liver, spleen, intestine and testis deteriorated with increasing doses and duration. The results suggest that S. oramin is sensitive to t-OP, and the above endpoints may be potential biomarkers for evaluating toxicities of environmental pollutants such as t-OP.

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Citations

Jul 1, 2014·General and Comparative Endocrinology·I TraversiA Mandich
Jan 27, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Iman Shirdel, Mohammad Reza Kalbassi
Sep 30, 2015·Cytotechnology·Burak Kaptaner
Mar 7, 2020·Ecotoxicology and Environmental Safety·Jerry Collince AcharJinho Jung

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