Toxic Effects of Lithium Chloride during Early Neonatal Period of Rat Development

Bulletin of Experimental Biology and Medicine
P N MenshanovN N Dygalo

Abstract

Lithium chloride (85, 255, or 255+127 μg/kg) or dexamethasone (0.2 or 2 mg/kg) were subcutaneously injected to 3-day-old rat pups, whose excretory system did not yet attain functional maturity. Both agents retarded the growth of rat pups and delayed the appearance of negative geotaxis. LD50 and therapeutic index of lithium chloride were 255 μg/kg and TI≤3, respectively. Thus, lithium salts even in low doses can be highly toxic for the developing organism.

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Sep 15, 2012·Bulletin of Experimental Biology and Medicine·P N MenshanovN N Dygalo
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Citations

Jan 30, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dena A-E MohammedR G Ahmed
Sep 17, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Dena A E MohammedAhmed R G

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