PMID: 9437810Jan 23, 1998Paper

Toxic effects of quinolone antibacterial agents on the musculoskeletal system in juvenile rats

Toxicologic Pathology
Y Kashida, M Kato

Abstract

Quinolone antibacterial agents have adverse effects on the musculoskeletal system in humans, consisting mainly of myalgia and arthralgia, and additionally of tendon disorders and rhabdomyolysis. The present study was conducted to examine the toxic effects of quinolones on the musculoskeletal system in juvenile rats using light microscopy, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry and electron microscopy. Single oral administration of 900 mg/kg pefloxacin (PFLX) or levofloxacin (LVFX) was found to induce lesions in the muscle + fascia, tendon + sheath, and synovial membrane, in addition to articular cartilage in the fore- and hindlimbs. Articular cartilage lesions were not necessarily associated with changes in the muscle, tendon, and synovial membrane, or the reverse. Among all lesions, the ankle and elbow showed the highest incidence and severity. Changes were more severe in the PFLX than in the LVFX group. Lesions in the muscle + fascia, tendon + sheath, and synovial membrane were similar and characterized by edema and increased number of mononuclear cells, many of which were positively stained with BrdU, as well as vascular endothelial cells in the Achilles tendon sheath and synovial membrane in the ankle. Electron...Continue Reading

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Citations

Jan 20, 2000·Antimicrobial Agents and Chemotherapy·M ShakibaeiR Stahlmann
Aug 17, 2000·Clinical Therapeutics·J Bertino, D Fish
Jun 23, 2009·Drug and Chemical Toxicology·Ahmet SaraçoğluOmer Colak
Feb 15, 2001·Expert Opinion on Investigational Drugs·O K KimJ F Barrett
Oct 17, 2012·Toxicology and Applied Pharmacology·Yang TanLiaobin Chen
Aug 16, 2011·Medical Hypotheses·Tolga Turker, Joseph E Kutz
Sep 15, 2006·Foot and Ankle Clinics·James F Griffith, Jason Brockwell
Nov 22, 2011·Hemodialysis International·Ankur GuptaRobert Bell
Jul 15, 2015·BMC Complementary and Alternative Medicine·Catherine BaugéKarim Boumediene
May 4, 2016·Pharmacotherapy·Monique R Bidell, Thomas P Lodise
Nov 25, 2004·The Annals of Pharmacotherapy·Shu-Hwa HsiaoTa-Jen Wu
Aug 22, 2014·The American Journal of Sports Medicine·Alice J S FoxScott A Rodeo
Jan 11, 2017·American Journal of Therapeutics·Ghulam Murtaza, Boonphiphop Boonpheng
Aug 14, 2019·Journal of Clinical Pharmacy and Therapeutics·Jeannette BouchardLouise-Marie Oleksiuk

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