PMID: 11322180Apr 27, 2001Paper

Toxic effects of sarin in rats at three months following single or repeated low-level inhalation exposure

Pharmacology & Toxicology
Jirí KassaZ Krocová

Abstract

Male albino Wistar rats were once or repeatedly exposed to three various low concentrations of sarin for 60 min. in the inhalation chamber. The clinical status of control as well as sarin-poisoned rats was tested 3 months after exposure to sarin using biochemical, haematological, neurophysiological, behavioural and immunotoxicological methods. While biochemical and haematological parameters, including the activities of cholinesterases in erythrocytes, plasma and various organs (brain, diaphragm), did not differ from the control values regardless of the sarin concentration used, few signs of sarin-induced neurotoxicity and immunotoxicity in sarin-poisoned rats were demonstrated. This was especially true when the single exposure of rats to non-convulsive symptomatic concentration and repeated exposure of rats to clinically asymptomatic concentration of sarin was used. In rats repeatedly poisoned with clinically asymptomatic concentrations of sarin, the alteration of the gait characterized by ataxia, the increase in the stereotyped behaviour, the increase in the excitability of the central nervous system following the administration of the convulsive drug pentamethylenetetrazol were observed. In rats poisoned with non-convulsive s...Continue Reading

Citations

Oct 22, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A W Abu-Qare, M B Abou-Donia
Apr 20, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Annetta WatsonVeronique Hauschild
Oct 26, 2006·Journal of Toxicology and Environmental Health. Part a·Raymond F GenoveseJessica C Bonnell
Sep 22, 2001·Pharmacology, Biochemistry, and Behavior·J KassaJ Vachek
Feb 2, 2016·Neurotoxicology and Teratology·C D SmithM L Sipos
Jun 9, 2011·Drug and Chemical Toxicology·Golime RamaRaoBijoy Krishna Bhattacharya
Nov 26, 2008·Neurotoxicology and Teratology·Raymond F GenoveseE Michael Jakubowski
Oct 7, 2008·Pharmacology, Biochemistry, and Behavior·Raymond F GenoveseJessica A Cooksey
May 20, 2008·Toxicology and Applied Pharmacology·Eugenia Bloch-ShildermanBen Avi Weissman
May 15, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Abdelaziz Ghanemi
Jul 12, 2016·Annals of the New York Academy of Sciences·David A Jett
Oct 18, 2011·Toxicology Letters·G RamaRao, B K Bhattacharya
Nov 3, 2010·Human & Experimental Toxicology·G RamaraoBk Bhattacharya
Jun 19, 2004·Inhalation Toxicology·Jiri BajgarHendrik P Benschop
Aug 27, 2005·Human & Experimental Toxicology·L Bartosova-Sevelova, J Bajgar
Jan 21, 2009·Journal of Applied Toxicology : JAT·Jaroslav PejchalLenka Zarybnicka

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