Toxic effects of some conifer resin acids and tea tree oil on human epithelial and fibroblast cells

Toxicology
T A SöderbergR Gref

Abstract

The present study was undertaken to assess and compare the in vitro cytotoxic effects of three resin acid analogues: dehydrobietic acid, podocarpic acid, O-methylpodocarpic acid; an essential oil from Australia (tea tree oil); and tapped oleoresin from Thailand, on human epithelial and fibroblast cells, using a quantitative neutral red spectrophotometric assay. All of the investigated compounds except for tea tree oil exhibited a cytotoxic activity which was proportional to their concentrations and time of exposure up to 24 h, i.e. higher concentrations and longer time of exposure caused increased cell death. Dehydroabietic acid and the oleoresin were the most toxic compounds followed by O-methylpodocarpic acid, whereas podocarpic acid and tea tree oil showed a lower level of toxicity. On the basis on these findings it is concluded that an isopropyl group on the aromatic C-ring is of great importance for the cytotoxicity of the tested abietane resin acids, thus indicating that the cytotoxic activity of oleoresins most probably is caused by synergistic or additive effects of resin acids. The results from this work support the view that antibacterial activity parallels cytotoxic activity which suggests a similar mode of action, m...Continue Reading

References

Jan 1, 1992·Archives of Dermatological Research·E GäfvertJ L Nilsson
Jan 1, 1992·The Australasian Journal of Dermatology·M M TongR S Barnetson
Feb 1, 1992·The British Journal of Dermatology·A T Karlberg, C Lidén
May 1, 1991·Journal of Ethnopharmacology·S BarelJ Yashphe
Jan 1, 1991·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·T A SöderbergG Hallmans
Jan 1, 1991·Chemico-biological Interactions·D M Toivola, B Isomaa
Jan 1, 1990·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·T A SöderbergG Hallmans
Mar 1, 1990·The Journal of Surgical Research·M L CooperD H Frank
Mar 1, 1989·The Journal of Allergy and Clinical Immunology·G H AyarsE Y Chi
Oct 1, 1985·Contact Dermatitis·A T KarlbergJ E Wahlberg
Aug 1, 1984·Bulletin of Environmental Contamination and Toxicology·A OikariB Holmbom
Mar 1, 1994·Journal of the American Academy of Dermatology·T E Knight, B M Hausen
Nov 7, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sheree E CrossMichael S Roberts
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E BorenfreundN Martin-Alguacil

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Citations

May 24, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M G EvandriG Mazzanti
Feb 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·R C BeierG E Spates
Mar 15, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A J Hayes, B Markovic
Jun 1, 1997·Burns : Journal of the International Society for Burn Injuries·J FaoagaliJ F Leditschke
Jun 5, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D A TiptonM Kh Dabbous
Jun 1, 1995·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A JohanssonR Gref
Mar 2, 2012·Chemotherapy·Akram AstaniPaul Schnitzler
Jun 10, 2004·Biological & Pharmaceutical Bulletin·Eui-Ju HongEui-Bae Jeung
Dec 17, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Akram AstaniPaul Schnitzler
Jun 1, 1996·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·D D NguyenT A Söderberg
Dec 10, 1999·Journal of Toxicology. Clinical Toxicology·A Woolf
Aug 18, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Silke NolkemperPaul Schnitzler
Mar 11, 2004·The Journal of Investigative Dermatology·Annarica CalcabriniAgnese Molinari
Nov 3, 2007·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C KochP Schnitzler
Nov 13, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F BakkaliM Idaomar
Mar 21, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mi Ja ChungSung-Joon Lee
Dec 18, 2003·Oral Microbiology and Immunology·K TakaradaT Kato
Jul 29, 2006·The Journal of Pharmacy and Pharmacology·Maren MöllerMichael Wink
Aug 5, 2009·Phytotherapy Research : PTR·Akram AstaniPaul Schnitzler
Feb 26, 2016·Journal of Toxicology and Environmental Health. Part a·Elena SturchioMauro Mecozzi
Feb 14, 2006·Complementary Therapies in Medicine·P J MaginW Smith
Oct 26, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K A HammerJ B Nielsen
Aug 16, 2005·Trends in Parasitology·Jean-Paul AnthonyHuw Smith
Jul 29, 2015·Poultry Science·Darin C BennettKimberly M Cheng
Aug 31, 2014·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M Heidary NavidP Schnitzler
Feb 28, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Rossella RussoLuigi Antonio Morrone
May 24, 2014·Natural Product Research·Michele CameroMaria Tempesta
Dec 14, 2017·Phytotherapy Research : PTR·Maísa CasarinFabricio Batistin Zanatta
May 30, 2009·Ultrastructural Pathology·Arno SipponenKari Lounatmaa
Dec 14, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Elisa SantovitoGiuseppina Avantaggiato
Jul 28, 2019·Antimicrobial Resistance and Infection Control·Bahman KhamenehBibi Sedigheh Fazly Bazzaz
Jul 12, 2020·Antibiotics·Bianca JohansenJean-Christophe Sergere
Nov 1, 2013·Pakistan Journal of Biological Sciences : PJBS·Ali Mohammad ArabzadehMahnaz Heidarbeigi
Nov 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia A LuchnikovaIrina B Ivshina
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Charles Elias AssmannIvana Beatrice Mânica da Cruz
Sep 1, 2005·Journal of Agricultural and Food Chemistry·Louis Kuoping ChaoShang-Tzen Chang

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