Toxic effects of thifluzamide on zebrafish (Danio rerio)

Journal of Hazardous Materials
Yang YangChengju Wang

Abstract

Thifluzamide is a fungicide widely used to control crop diseases, and it therefore constitutes a hazard to the environment. In this study, zebrafish were selected to assess the aquatic toxicity of thifluzamide. The acute and development toxicity of thifluzamide to embryos, larvae, and adult zebrafish were measured and the corresponding 96h-LC50 values were as follows: adult fish (4.19mg/L) <larvae (3.52mg/L) <embryos (3.08mg/L). A large suite of symptoms was found in these three stages of zebrafish, including abnormal spontaneous movement, slow heartbeat, hatching inhibition, growth regression, and morphological deformities. In addition, for adult zebrafish, distinct pathological changes were noted in liver and kidney 21 days post exposure (dpe) to 0.19, 1.33, and 2.76mg/L. Liver damage was more severe than kidney damage. In another 28 days exposure of adult zebrafish to 0.019, 0.19, and 1.90mg/L, negative changes in mitochondrial structure and enzymes activities [succinate dehydrogenase (SDH) and respiratory chain complexes] were found. These might be responsible for the adverse expansion of the apoptosis- and immune-related genes, which would facilitate the action of these factors in programmed cell death and might play a key...Continue Reading

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Citations

Jun 8, 2018·Environmental Science and Pollution Research International·Hongzhou YaoChao Xu
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Nov 24, 2020·Environmental Science and Pollution Research International·Carla Eliana DavicoEvelise Maria Nazari
Nov 13, 2019·Ecotoxicology and Environmental Safety·Xiangfeng YaoXingyin Jiang
Jan 23, 2021·The Science of the Total Environment·Hai LinJie Chen
Mar 12, 2021·Environmental Science and Pollution Research International·Mingrui YuanPeng Xiao
Apr 10, 2018·The Science of the Total Environment·Le QianChengju Wang
Dec 2, 2020·Journal of Hazardous Materials·Siliang YuanChunsheng Liu
May 26, 2021·The Science of the Total Environment·You WengYuanxiang Jin
Jul 17, 2021·Journal of Agricultural and Food Chemistry·Xiangguang ChenChengju Wang
Jul 4, 2021·Environmental Science and Pollution Research International·Falin HeRutao Liu

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