Toxic epidermal necrolysis and fluoxetine: a case report

Journal of Clinical Psychopharmacology
Gregory W JonssonFatima Y Jeenah

Abstract

Toxic epidermal necrolysis (TEN) is a distinct clinical entity within a spectrum of adverse cutaneous drug reactions. It is characterized by >30% of the body surface area of skin detachment with an average reported mortality of 25-35%. Drug induced TEN is associated with various antibiotics, anticonvulsants and other drugs. While adverse cutaneous drug reactions are common with antidepressants, the majority eruptions are benign and easily treated. TEN is rarely reported in association with selective serotonin reuptake inhibitors (SSRI's). We describe TEN in a 34-year-old patient from Mozambique associated with the addition of fluoxetine for a major depressive episode with psychotic features.

References

Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Jun 19, 2002·American Journal of Clinical Dermatology·Julia K Warnock, David W Morris
Oct 20, 2004·The Journal of Clinical Psychiatry·Nicholas Tsvi WeissJohn C Chamberlain
May 7, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Erik LetkoC Stephen Foster
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Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Lars E French

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Citations

Oct 9, 2018·Journal of Clinical Pharmacy and Therapeutics·Rohit AgrawalSeema Gandhi
Dec 12, 2018·Drug Safety - Case Reports·Josiah Tatenda MasukaDixon Chibanda

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